Fentanyl Drug Interactions
Currently displaying a list of 634 drugs known to interact with fentanyl.
- 259 major drug interactions
- 371 moderate drug interactions
- 4 minor drug interactions
Medications known to interact with fentanyl
Note: Showing generic names only.
5
A
- abametapir topical
- acebutolol
- acetylcarbromal
- acrivastine
- adagrasib
- adalimumab
- aldesleukin
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- almotriptan
- alprazolam
- alvimopan
- amifampridine
- amiloride
- aminoglutethimide
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- amyl nitrite
- anakinra
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- aripiprazole
- armodafinil
- asciminib
- asenapine
- atazanavir
- atenolol
- atezolizumab
- atomoxetine
- atracurium
- atropine
- avacopan
- avelumab
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- baricitinib
- belladonna
- belzutifan
- benazepril
- bendroflumethiazide
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betaxolol
- bexarotene
- bimekizumab
- biperiden
- bisoprolol
- blinatumomab
- boceprevir
- bosentan
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- canakinumab
- candesartan
- cannabidiol
- cannabis
- capivasertib
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carvedilol
- cemiplimab
- cenobamate
- ceritinib
- cetirizine
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- cimetidine
- cisatracurium
- citalopram
- clarithromycin
- clemastine
- clevidipine
- clidinium
- clobazam
- clofazimine
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clotrimazole
- clozapine
- cobicistat
- codeine
- conivaptan
- cosibelimab
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclosporine
- cyproheptadine
D
- dabrafenib
- danazol
- dantrolene
- daridorexant
- darifenacin
- darunavir
- dasatinib
- deferasirox
- delavirdine
- desflurane
- desipramine
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dicyclomine
- difelikefalin
- dihydroergotamine
- diltiazem
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- dolasetron
- dostarlimab
- doxacurium
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
- durvalumab
- duvelisib
E
- echinacea
- efavirenz
- elafibranor
- elagolix
- eletriptan
- elranatamab
- eluxadoline
- emapalumab
- enalapril
- enalaprilat
- encorafenib
- enflurane
- entacapone
- entrectinib
- enzalutamide
- epcoritamab
- eplerenone
- eprosartan
- erdafitinib
- ergotamine
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- estradiol
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- etrasimod
- etravirine
- evening primrose
- ezogabine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fesoterodine
- fexinidazole
- flavoxate
- flibanserin
- fluconazole
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fospropofol
- fostamatinib
- frovatriptan
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gepirone
- ginkgo
- givinostat
- glofitamab
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- golimumab
- granisetron
- grepafloxacin
- griseofulvin
- guanethidine
- guanfacine
- guselkumab
H
- halazepam
- haloperidol
- halothane
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyzine
- hyoscyamine
I
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- indapamide
- indinavir
- indocyanine green
- infliximab
- iohexol
- iomeprol
- iopamidol
- ipilimumab
- iptacopan
- irbesartan
- isavuconazonium
- isocarboxazid
- isoflurane
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- itraconazole
- ivacaftor
- ivosidenib
K
L
- labetalol
- lamotrigine
- landiolol
- lanreotide
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- lesinurad
- letermovir
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lindane topical
- linezolid
- lisdexamfetamine
- lisinopril
- lithium
- lofexidine
- lonafarnib
- lonapegsomatropin
- lorazepam
- lorcaserin
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
M
- maprotiline
- mavacamten
- mavorixafor
- mazindol
- mebrofenin
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methoxyflurane
- methscopolamine
- methsuximide
- methyldopa
- methylene blue
- metoclopramide
- metocurine
- metolazone
- metoprolol
- metreleptin
- metrizamide
- metyrosine
- mibefradil
- miconazole
- midazolam
- mifepristone
- milnacipran
- minoxidil
- mirtazapine
- mitapivat
- mitotane
- mivacurium
- mobocertinib
- modafinil
- moexipril
- molindone
- morphine
- morphine liposomal
- mosunetuzumab
N
- nabilone
- nadolol
- nafcillin
- nalbuphine
- naloxone
- naltrexone
- naratriptan
- nebivolol
- nefazodone
- nelfinavir
- nemolizumab
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nirogacestat
- nisoldipine
- nitroglycerin
- nitroprusside
- nitrous oxide
- nivolumab
- nortriptyline
O
- octreotide
- olanzapine
- olaparib
- oliceridine
- olmesartan
- olopatadine nasal
- olutasidenib
- omaveloxolone
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- osimertinib
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- ozanimod
P
- pacritinib
- palbociclib
- paliperidone
- palonosetron
- pancuronium
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- pazopanib
- pegvisomant
- pembrolizumab
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenylbutazone
- phenytoin
- pimozide
- pindolol
- pipecuronium
- pirtobrutinib
- pitolisant
- polyethylene glycol 3350 with electrolytes
- polythiazide
- posaconazole
- pralsetinib
- pramipexole
- prasugrel
- prazosin
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- ramelteon
- ramipril
- ranolazine
- rapacuronium
- rasagiline
- remdesivir
- remifentanil
- remimazolam
- repotrectinib
- reserpine
- retifanlimab
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- risperidone
- ritlecitinib
- ritonavir
- rizatriptan
- rocuronium
- ropeginterferon alfa-2b
- ropinirole
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- saquinavir
- sarilumab
- satralizumab
- scopolamine
- secobarbital
- secukinumab
- selegiline
- selpercatinib
- sertraline
- sevoflurane
- sibutramine
- sildenafil
- silodosin
- siltuximab
- sirolimus
- sodium oxybate
- sodium polystyrene sulfonate
- sofpironium topical
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotalol
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- succinylcholine
- sufentanil
- sulfinpyrazone
- sumatriptan
- suvorexant
- suzetrigine
T
- tacrolimus
- talquetamab
- tamsulosin
- tapentadol
- tarlatamab
- tasimelteon
- tazemetostat
- tebentafusp
- teclistamab
- tecovirimat
- tedizolid
- telaprevir
- telithromycin
- telmisartan
- telotristat
- temazepam
- temsirolimus
- terazosin
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticagrelor
- timolol
- tislelizumab
- tizanidine
- tocilizumab
- tofacitinib
- tolcapone
- tolterodine
- topiramate
- toripalimab
- torsemide
- tovorafenib
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- tremelimumab
- treosulfan
- triamterene
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trofinetide
- troglitazone
- troleandomycin
- trospium
- tryptophan
- tubocurarine
- tucatinib
U
V
- vadadustat
- valbenazine
- valerian
- valproic acid
- valsartan
- vecuronium
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- vinorelbine
- vonoprazan
- vorasidenib
- voriconazole
- vortioxetine
- voxelotor
Z
Fentanyl alcohol/food interactions
There is 1 alcohol/food interaction with fentanyl.
Fentanyl disease interactions
There are 17 disease interactions with fentanyl which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- fever
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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