Ibuprofen PM Interactions
There are 758 drugs known to interact with Ibuprofen PM (diphenhydramine/ibuprofen), along with 19 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 114 are major, 630 are moderate, and 14 are minor.
- View all 758 medications that may interact with Ibuprofen PM
- View Ibuprofen PM alcohol/food interactions (2)
- View Ibuprofen PM disease interactions (19)
Most frequently checked interactions
View interaction reports for Ibuprofen PM (diphenhydramine / ibuprofen) and the medicines listed below.
- acetaminophen
- albuterol
- amitriptyline
- amlodipine
- aspirin
- atorvastatin
- Benadryl (diphenhydramine)
- clonazepam
- cyclobenzaprine
- furosemide
- gabapentin
- hydrochlorothiazide
- ibuprofen
- levothyroxine
- lisinopril
- losartan
- melatonin
- meloxicam
- metformin
- naproxen
- omeprazole
- pantoprazole
- Paracetamol (acetaminophen)
- prednisone
- sertraline
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
Ibuprofen PM alcohol/food interactions
There are 2 alcohol/food interactions with Ibuprofen PM (diphenhydramine / ibuprofen).
Ibuprofen PM disease interactions
There are 19 disease interactions with Ibuprofen PM (diphenhydramine / ibuprofen) which include:
- depression
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- PKU
- anemia
- hepatotoxicity
- hyperkalemia
- platelet aggregation inhibition
Report options
More about Ibuprofen PM (diphenhydramine / ibuprofen)
- Ibuprofen PM consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (3)
- Imprints, shape & color data
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Cyclobenzaprine
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Meloxicam
Meloxicam is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Aspirin
Aspirin is used to treat mild to moderate pain and to reduce fever or inflammation. Learn about ...
Naproxen
Naproxen is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Oxycodone
Oxycodone is an opioid analgesic used to treat moderate to severe pain; it has a high potential for ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.