Siladryl Interactions
There are 448 drugs known to interact with Siladryl (diphenhydramine), along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 14 are major, 432 are moderate, and 2 are minor.
- View all 448 medications that may interact with Siladryl
- View Siladryl alcohol/food interactions (1)
- View Siladryl disease interactions (8)
Most frequently checked interactions
View interaction reports for Siladryl (diphenhydramine) and the medicines listed below.
- acetaminophen / butalbital / caffeine
- acetaminophen / hydrocodone
- Airsupra (albuterol / budesonide)
- albuterol
- alprazolam
- Alvesco (ciclesonide)
- Ambien CR (zolpidem)
- amitriptyline
- Auvi-Q (epinephrine)
- azelastine nasal
- baclofen
- Belsomra (suvorexant)
- betamethasone
- bisacodyl
- budesonide
- bupropion
- cannabidiol
- Celebrex (celecoxib)
- Celestone (betamethasone)
- cetirizine
- chlorpheniramine / hydrocodone
- chromium picolinate
- Cipro (ciprofloxacin)
- clindamycin topical
- clonazepam
- colestipol
- Corlanor (ivabradine)
- cromolyn
- fluoxetine
- rizatriptan
Siladryl alcohol/food interactions
There is 1 alcohol/food interaction with Siladryl (diphenhydramine).
Siladryl disease interactions
There are 8 disease interactions with Siladryl (diphenhydramine) which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
More about Siladryl (diphenhydramine)
- Compare alternatives
- Latest FDA alerts (2)
- Side effects
- Dosage information
- During pregnancy
- Drug class: anticholinergic antiemetics
- Breastfeeding
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.