Dextromethorphan/pyrilamine Interactions
There are 532 drugs known to interact with dextromethorphan/pyrilamine, along with 7 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 85 are major, 444 are moderate, and 3 are minor.
- View dextromethorphan/pyrilamine alcohol/food interactions (2)
- View dextromethorphan/pyrilamine disease interactions (7)
Medications known to interact with dextromethorphan/pyrilamine
Note: Showing generic names only.
5
A
- abametapir topical
- abiraterone
- abobotulinumtoxinA
- acebutolol
- acetylcarbromal
- acetylcholine ophthalmic
- aclidinium
- acrivastine
- adagrasib
- adalimumab
- aldesleukin
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- almotriptan
- alprazolam
- amantadine
- amiloride
- amiodarone
- amisulpride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amyl nitrite
- anakinra
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- aripiprazole
- asenapine
- atenolol
- atomoxetine
- atropine
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- belladonna
- benazepril
- bendroflumethiazide
- benzgalantamine
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betaxolol
- bimekizumab
- biperiden
- bisoprolol
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- canakinumab
- candesartan
- cannabidiol
- cannabis
- capivasertib
- captopril
- carbachol ophthalmic
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- celecoxib
- cenobamate
- cetirizine
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- cimetidine
- cinacalcet
- citalopram
- clemastine
- clevidipine
- clidinium
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- codeine
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dacomitinib
- danicopan
- dantrolene
- daridorexant
- darifenacin
- daxibotulinumtoxinA
- delavirdine
- demecarium bromide ophthalmic
- deserpidine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dextroamphetamine
- dezocine
- diazepam
- diazoxide
- dicyclomine
- difelikefalin
- dihydroergotamine
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- dolasetron
- donepezil
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
E
- echothiophate iodide ophthalmic
- efavirenz
- elacestrant
- eletriptan
- eliglustat
- eluxadoline
- emapalumab
- enalapril
- enalaprilat
- entacapone
- epcoritamab
- eplerenone
- eprosartan
- ergotamine
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- ezogabine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenoldopam
- fentanyl
- fesoterodine
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosinopril
- fosphenytoin
- fospropofol
- fostamatinib
- frovatriptan
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- gepirone
- givosiran
- glofitamab
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- golimumab
- granisetron
- guanabenz
- guanadrel
- guanethidine
- guanfacine
- guselkumab
H
- halazepam
- halofantrine
- haloperidol
- heroin
- histamine phosphate
- house dust mite allergen extract
- hyaluronidase
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxychloroquine
- hydroxyzine
- hyoscyamine
I
- ifosfamide
- iloperidone
- imatinib
- imipramine
- incobotulinumtoxinA
- indapamide
- infliximab
- ipratropium
- ipratropium nasal
- irbesartan
- isocarboxazid
- isoflurophate ophthalmic
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
K
L
- labetalol
- lamotrigine
- landiolol
- lasmiditan
- lemborexant
- lenacapavir
- letibotulinumtoxinA
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- linezolid
- lisdexamfetamine
- lisinopril
- lithium
- lofexidine
- lonapegsomatropin
- loperamide
- lorazepam
- lorcaserin
- losartan
- loxapine
- lumateperone
- lurasidone
M
- maprotiline
- maribavir
- mavorixafor
- mazindol
- meclizine
- melatonin
- memantine
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methscopolamine
- methsuximide
- methyclothiazide
- methyldopa
- methylene blue
- metoclopramide
- metolazone
- metoprolol
- metyrosine
- mibefradil
- midazolam
- milnacipran
- minoxidil
- mirabegron
- mirtazapine
- mitotane
- mixed grass pollens allergen extract
- moexipril
- molindone
- momelotinib
- morphine
- morphine liposomal
N
- nabilone
- nadolol
- nalbuphine
- naratriptan
- nebivolol
- nefazodone
- nemolizumab
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nisoldipine
- nitroglycerin
- nitroprusside
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- olutasidenib
- omaveloxolone
- onabotulinumtoxinA
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- oxamniquine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- ozanimod
P
- paliperidone
- palonosetron
- panobinostat
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- peanut allergen powder
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenytoin
- physostigmine
- physostigmine ophthalmic
- pilocarpine ophthalmic
- pimozide
- pindolol
- pirtobrutinib
- pitolisant
- polythiazide
- potassium chloride
- potassium citrate
- prabotulinumtoxinA
- pralsetinib
- pramipexole
- prazosin
- pregabalin
- pretomanid
- primidone
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propantheline
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
Q
R
- ragweed pollen allergen extract
- ramelteon
- ramipril
- ranolazine
- rasagiline
- rauwolfia serpentina
- remifentanil
- remimazolam
- reserpine
- revefenacin
- rilonacept
- rimabotulinumtoxinB
- risperidone
- ritonavir
- rivastigmine
- rizatriptan
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- rotigotine
- rufinamide
S
- safinamide
- sarilumab
- satralizumab
- scopolamine
- secobarbital
- secukinumab
- selegiline
- sertraline
- sibutramine
- silodosin
- siltuximab
- sodium iodide i-123
- sodium iodide-i-131
- sodium oxybate
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotalol
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sumatriptan
- suvorexant
T
- tacrine
- tamsulosin
- tapentadol
- tarlatamab
- tasimelteon
- tebentafusp
- teclistamab
- tedizolid
- telmisartan
- temazepam
- terazosin
- terbinafine
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticlopidine
- timolol
- timothy grass pollen allergen extract
- tiotropium
- tirzepatide
- tizanidine
- tocilizumab
- tolcapone
- tolterodine
- topiramate
- torsemide
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- triamterene
- triazolam
- trichlormethiazide
- trichophyton skin test
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- troglitazone
- trospium
- tryptophan
U
V
- valbenazine
- valdecoxib
- valerian
- valproic acid
- valsartan
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- vimseltinib
- vortioxetine
Z
Dextromethorphan/pyrilamine alcohol/food interactions
There are 2 alcohol/food interactions with dextromethorphan / pyrilamine.
Dextromethorphan/pyrilamine disease interactions
There are 7 disease interactions with dextromethorphan / pyrilamine which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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