Dextromethorphan/promethazine Interactions
There are 755 drugs known to interact with dextromethorphan/promethazine, along with 13 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 164 are major, 578 are moderate, and 13 are minor.
- View all 755 medications that may interact with dextromethorphan/promethazine
- View dextromethorphan/promethazine alcohol/food interactions (2)
- View dextromethorphan/promethazine disease interactions (13)
Most frequently checked interactions
View interaction reports for dextromethorphan / promethazine and the medicines listed below.
- Ajovy (fremanezumab)
- Ambien (zolpidem)
- Ativan (lorazepam)
- Azithromycin Dose Pack (azithromycin)
- Benadryl (diphenhydramine)
- Bentyl (dicyclomine)
- BuSpar (buspirone)
- Cymbalta (duloxetine)
- Dilaudid (hydromorphone)
- Elavil (amitriptyline)
- Eliquis (apixaban)
- Flonase (fluticasone nasal)
- Halcion (triazolam)
- Imitrex (sumatriptan)
- Iron Fumarate (ferrous fumarate)
- Klonopin (clonazepam)
- Klor-Con (potassium chloride)
- Lexapro (escitalopram)
- Lomotil (atropine / diphenoxylate)
- Lunesta (eszopiclone)
- Lyrica (pregabalin)
- Maxalt (rizatriptan)
- Neurontin (gabapentin)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- Paxlovid (nirmatrelvir / ritonavir)
- Synthroid (levothyroxine)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zyprexa (olanzapine)
Dextromethorphan/promethazine alcohol/food interactions
There are 2 alcohol/food interactions with dextromethorphan / promethazine.
Dextromethorphan/promethazine disease interactions
There are 13 disease interactions with dextromethorphan / promethazine which include:
- acute alcohol intoxication
- CNS depression
- hematologic toxicity
- hypotension
- liver disease
- antidopaminergic effects 1
- asthma
- anticholinergic effects
- asthma/COPD
- breast cancer
- NMS
- seizure disorders
- antidopaminergic effects 2
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More about dextromethorphan / promethazine
- dextromethorphan/promethazine consumer information
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- Reviews (48)
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.