Dextromethorphan/promethazine Interactions
There are 752 drugs known to interact with dextromethorphan/promethazine, along with 13 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 163 are major, 576 are moderate, and 13 are minor.
- View all 752 medications that may interact with dextromethorphan/promethazine
- View dextromethorphan/promethazine alcohol/food interactions (2)
- View dextromethorphan/promethazine disease interactions (13)
Most frequently checked interactions
View interaction reports for dextromethorphan / promethazine and the medicines listed below.
- Ajovy (fremanezumab)
- Ajovy (fremanezumab)
- Ativan (lorazepam)
- Ativan (lorazepam)
- Benadryl (diphenhydramine)
- Benadryl (diphenhydramine)
- Bentyl (dicyclomine)
- Bentyl (dicyclomine)
- BuSpar (buspirone)
- BuSpar (buspirone)
- Cymbalta (duloxetine)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Eliquis (apixaban)
- Flonase (fluticasone nasal)
- Flonase (fluticasone nasal)
- Lexapro (escitalopram)
- Lexapro (escitalopram)
- Lyrica (pregabalin)
- Lyrica (pregabalin)
- Norco (acetaminophen / hydrocodone)
- Norco (acetaminophen / hydrocodone)
- Synthroid (levothyroxine)
- Synthroid (levothyroxine)
- Xanax (alprazolam)
- Xanax (alprazolam)
- Zofran (ondansetron)
- Zofran (ondansetron)
- Zyprexa (olanzapine)
- Zyprexa (olanzapine)
Dextromethorphan/promethazine alcohol/food interactions
There are 2 alcohol/food interactions with dextromethorphan / promethazine.
Dextromethorphan/promethazine disease interactions
There are 13 disease interactions with dextromethorphan / promethazine which include:
- acute alcohol intoxication
- CNS depression
- hematologic toxicity
- hypotension
- liver disease
- antidopaminergic effects 1
- asthma
- anticholinergic effects
- asthma/COPD
- breast cancer
- NMS
- seizure disorders
- antidopaminergic effects 2
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More about dextromethorphan / promethazine
- dextromethorphan/promethazine consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (47)
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.