Codeine/phenylephrine Interactions
There are 647 drugs known to interact with codeine/phenylephrine, along with 20 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 143 are major, 502 are moderate, and 2 are minor.
- View all 647 medications that may interact with codeine/phenylephrine
- View codeine/phenylephrine alcohol/food interactions (2)
- View codeine/phenylephrine disease interactions (20)
Most frequently checked interactions
View interaction reports for codeine / phenylephrine and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Adderall XR (amphetamine / dextroamphetamine)
- Advair Diskus (fluticasone / salmeterol)
- Advil (ibuprofen)
- Afrin NoDrip Extra Moisturizing (oxymetazoline nasal)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Aleve (naproxen)
- Allegra Allergy (fexofenadine)
- Amoclan (amoxicillin / clavulanate)
- Azithromycin Dose Pack (azithromycin)
- Bactrim (sulfamethoxazole / trimethoprim)
- Benadryl (diphenhydramine)
- Benadryl Allergy (diphenhydramine)
- Botox (onabotulinumtoxinA)
- Calcium 600 D (calcium / vitamin d)
- Celebrex (celecoxib)
- Centrum Silver Women's (multivitamin with minerals)
- Claritin 24 Hour Allergy (loratadine)
- Colace (docusate)
- Compazine (prochlorperazine)
- Cosentyx (secukinumab)
- Cymbalta (duloxetine)
- Diphen (diphenhydramine)
- Diurex Aquagels (pamabrom)
- Dulcolax Laxative (bisacodyl)
- Effexor XR (venlafaxine)
- Elavil (amitriptyline)
- Elmiron (pentosan polysulfate sodium)
- Emgality (galcanezumab)
- Enbrel (etanercept)
Codeine/phenylephrine alcohol/food interactions
There are 2 alcohol/food interactions with codeine / phenylephrine.
Codeine/phenylephrine disease interactions
There are 20 disease interactions with codeine / phenylephrine which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- cardiovascular disease
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
- BPH
- diabetes
- glaucoma
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More about codeine / phenylephrine
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.