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Codeine / phenylephrine Side Effects

Applies to codeine / phenylephrine: oral liquid

General

The more commonly reported adverse effects have included nausea, vomiting, and dizziness.[Ref]

Respiratory

Respiratory depression has been associated with antitussive use of codeine in young children. Respiratory depression and death have occurred in children who received codeine in the postoperative period following tonsillectomy and/or adenoidectomy. Further investigation has shown these patients to be ultra-rapid metabolizers of codeine. Children with obstructive sleep apnea who are treated with codeine appear to be particularly sensitive to the respiratory depressant effects of codeine.[Ref]

Codeine:

Frequency not reported: Respiratory depression

Phenylephrine:

Frequency not reported: Respiratory distress[Ref]

Gastrointestinal

Patients with chronic ulcerative colitis may experience increased colonic motility, while patients with acute ulcerative colitis have experienced toxic dilation with codeine use.[Ref]

Codeine

Frequency not reported: Nausea, vomiting, constipation, biliary tract spasm, increased colonic motility, toxic dilation[Ref]

Cardiovascular

Codeine

Frequency not reported: Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension, circulatory depression

Phenylephrine:

Frequency not reported: Ischemia[Ref]

Dermatologic

Codeine:

Frequency not reported: Rash[Ref]

Hypersensitivity

Codeine

Frequency not reported: Pruritus, giant urticaria, angioneurotic edema, laryngeal edema[Ref]

Psychiatric

Codeine

Frequency not reported: Euphoria, dysphoria, transient hallucination, disorientation

Phenylephrine:

Frequency not reported: Anxiety, nervousness[Ref]

Nervous system

Codeine

Frequency not reported: CNS depression, lightheadedness, dizziness, sedation, headache, convulsions, weakness

Phenylephrine:

Frequency not reported: Restlessness, dizziness, tremor, weakness[Ref]

Genitourinary

Codeine

Frequency not reported: Oliguria, urinary retention, antidiuretic effect[Ref]

Ocular

Codeine

Frequency not reported: Visual disturbances[Ref]

Other

Phenylephrine:

Frequency not reported: Pain[Ref]

References

1. "Product Information. Ala-Hist AC (codeine-phenylephrine)." Poly Pharmaceuticals Inc, Quitman, MS.

2. "Product Information. Promethazine VC with Codeine (codeine / phenylephrine/promethazine)." Par Pharmaceutical Inc (formerly Qualitest Pharmaceuticals Inc), Huntsville, AL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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