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Drug Interactions between clonidine and Procardia XL

This report displays the potential drug interactions for the following 2 drugs:

  • clonidine
  • Procardia XL (nifedipine)

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Interactions between your drugs


cloNIDine NIFEdipine

Applies to: clonidine and Procardia XL (nifedipine)

Before taking cloNIDine, tell your doctor if you also use NIFEdipine. You may need dose adjustments or special tests in order to safely take both medications together. This combination may have additive effects on lowering your blood pressure. You should take cloNIDine at bedtime and notify your doctor if you feel dizzy or faint. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor.

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Drug and food interactions


NIFEdipine food

Applies to: Procardia XL (nifedipine)

You should avoid or limit the consumption of grapefruit and grapefruit juice if you are receiving treatment with NIFEdipine. Grapefruit juice can significantly increase the blood levels and effects of medications like NIFEdipine. You may be more likely to experience side effects such as headache, low blood pressure, irregular heartbeat, swelling, and fluid retention. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.