Xanax XR Drug Interactions
Currently displaying a list of 562 drugs known to interact with Xanax XR (alprazolam).
- 55 major drug interactions
- 467 moderate drug interactions
- 40 minor drug interactions
Medications known to interact with Xanax XR
Note: Showing generic names only.
A
- abametapir topical
- acebutolol
- acetazolamide
- acetylcarbromal
- acrivastine
- adagrasib
- adalimumab
- aldesleukin
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- aluminum carbonate
- aluminum hydroxide
- amiloride
- aminophylline
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amprenavir
- amyl nitrite
- anagrelide
- anakinra
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- aripiprazole
- armodafinil
- asciminib
- asenapine
- atazanavir
- atenolol
- atracurium
- avacopan
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- belzutifan
- benazepril
- bendroflumethiazide
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betamethasone
- betaxolol
- bexarotene
- bimekizumab
- biperiden
- bisoprolol
- boceprevir
- bosentan
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bumetanide
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- calcium carbonate
- canakinumab
- candesartan
- cannabidiol
- cannabis
- capivasertib
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- cenobamate
- ceritinib
- cetirizine
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- cimetidine
- cisatracurium
- citalopram
- clarithromycin
- clemastine
- clevidipine
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clotrimazole
- clozapine
- cobicistat
- codeine
- conivaptan
- crizotinib
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dabrafenib
- dantrolene
- daridorexant
- darunavir
- dasatinib
- deferasirox
- dehydroepiandrosterone
- delavirdine
- deserpidine
- desflurane
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dichlorphenamide
- didanosine
- difelikefalin
- digoxin
- dihydroxyaluminum sodium carbonate
- diltiazem
- dimenhydrinate
- diphenhydramine
- disulfiram
- divalproex sodium
- doxacurium
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
- duvelisib
- dyphylline
E
- echinacea
- efavirenz
- eliglustat
- emapalumab
- enalapril
- enalaprilat
- encorafenib
- enflurane
- entacapone
- entrectinib
- enzalutamide
- eplerenone
- eprosartan
- erdafitinib
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etravirine
- ezogabine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenoldopam
- fentanyl
- fexinidazole
- flavoxate
- flibanserin
- fluconazole
- flumazenil
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fospropofol
- fostamatinib
- furosemide
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- givinostat
- glofitamab
- glycerol phenylbutyrate
- golimumab
- grepafloxacin
- guanabenz
- guanadrel
- guanethidine
- guanfacine
- guselkumab
H
- halazepam
- haloperidol
- halothane
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyzine
I
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- indapamide
- indinavir
- infliximab
- iptacopan
- irbesartan
- isavuconazonium
- isocarboxazid
- isoflurane
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- itraconazole
- ivacaftor
- ivosidenib
K
L
- labetalol
- lamotrigine
- landiolol
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- letermovir
- levamlodipine
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levorphanol
- lidocaine
- lisinopril
- lithium
- lofexidine
- lomitapide
- lonafarnib
- lonapegsomatropin
- lorazepam
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
M
- magaldrate
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- maprotiline
- mavacamten
- mavorixafor
- meclizine
- melatonin
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methazolamide
- methdilazine
- methocarbamol
- methohexital
- methoxyflurane
- methsuximide
- methyclothiazide
- methyldopa
- methylprednisolone
- metoclopramide
- metocurine
- metolazone
- metoprolol
- metyrosine
- mibefradil
- miconazole
- midazolam
- mifepristone
- minoxidil
- mirtazapine
- mitapivat
- mitotane
- mivacurium
- mobocertinib
- modafinil
- moexipril
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nadolol
- nalbuphine
- nebivolol
- nefazodone
- nelfinavir
- nemolizumab
- nevirapine
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- nirogacestat
- nisoldipine
- nitroglycerin
- nitroprusside
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- olutasidenib
- omaveloxolone
- omeprazole
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- oxazepam
- oxcarbazepine
- oxtriphylline
- oxycodone
- oxymorphone
P
- pacritinib
- paliperidone
- pancuronium
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentolamine
- phenytoin
- pimozide
- pindolol
- pipecuronium
- pirtobrutinib
- polythiazide
- porfimer
- posaconazole
- pralsetinib
- pramipexole
- prazosin
- prednisolone
- prednisone
- pregabalin
- prilocaine
- primidone
- probenecid
- procaine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- ramelteon
- ramipril
- rapacuronium
- rasagiline
- rauwolfia serpentina
- remdesivir
- remifentanil
- remimazolam
- repotrectinib
- reserpine
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- risperidone
- ritlecitinib
- ritonavir
- rocuronium
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- saquinavir
- sarilumab
- satralizumab
- scopolamine
- secobarbital
- secukinumab
- selegiline
- selpercatinib
- sertraline
- sevoflurane
- sibutramine
- silodosin
- siltuximab
- sirolimus
- sodium bicarbonate
- sodium citrate
- sodium iodide i-123
- sodium iodide-i-131
- sodium oxybate
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotalol
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- succinylcholine
- sufentanil
- suvorexant
- suzetrigine
T
- tacrolimus
- talquetamab
- tamsulosin
- tapentadol
- tasimelteon
- tazemetostat
- tebentafusp
- tecovirimat
- teduglutide
- telaprevir
- telithromycin
- telmisartan
- telotristat
- temazepam
- temsirolimus
- terazosin
- tetrabenazine
- tetracaine
- thalidomide
- theophylline
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- timolol
- tizanidine
- tocilizumab
- tolcapone
- topiramate
- torsemide
- tovorafenib
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- treosulfan
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trofinetide
- troglitazone
- troleandomycin
- tubocurarine
- tucatinib
U
V
- vadadustat
- valbenazine
- valerian
- valproic acid
- valsartan
- vecuronium
- venlafaxine
- verapamil
- vigabatrin
- viloxazine
- vorasidenib
- voriconazole
- voxelotor
Z
Xanax XR alcohol/food interactions
There are 2 alcohol/food interactions with Xanax XR (alprazolam).
Xanax XR disease interactions
There are 9 disease interactions with Xanax XR (alprazolam) which include:
- acute alcohol intoxication
- closed-angle glaucoma
- drug dependence
- renal/liver disease
- respiratory depression
- seizures
- depression
- obesity
- paradoxical reactions
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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