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Acetaminophen / dextromethorphan Drug Interactions

A total of 718 drugs are known to interact with acetaminophen / dextromethorphan.

  • 157 major drug interactions
  • 501 moderate drug interactions
  • 60 minor drug interactions

Show all medications in the database that may interact with acetaminophen / dextromethorphan.

Check for interactions with acetaminophen / dextromethorphan

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Common medications checked in combination with acetaminophen / dextromethorphan

  • acetaminophen / dextromethorphan / phenylephrine (Vicks Dayquil Cold & Flu Relief, Comtrex Cold & Cough, Neocitran Non Drowsy Extra Strength Cold and Flu, Mapap Cold Formula, Vicks Dayquil Cold & Flu Symptom Relief Plus Vitamin C, Tylenol Cold Max Day, Robitussin Peak Cold Daytime Cold + Flu, Daytime Cold & Flu, Contac Complete Cough, Cold & Flu Extra Strength, Tylenol Plus Children's Cold & Cough, Robitussin Cold + Flu (Daytime), Little Colds Multi-Symptom, Vicks Nature Fusion Cold & Flu Multi-Symptom Relief, Theraflu Daytime Severe Cold & Cough, Comtrex Cold and Cough Maximum Strength, Day Relief PE, Day Time Multi-Symptom Cold/Flu Relief, Multi Symptom Cold (Day Formula), Alka-Seltzer Plus Severe Sinus Congestion & Cough Liquid Gels, Alka-Seltzer Plus Maximum Strength Day Cold & Flu Liquid Gels, Alka-Seltzer Plus Maximum Strength Day & Night Cold & Flu Liquid Gels (Day Formula), Alka-Seltzer Plus Severe Sinus Congestion & Cough (Day Formula), Alka-Seltzer Plus Multi-Symptom Cold & Flu Day Liquid Gels, Theraflu Multi-Symptom Severe Cold with Lipton Flavors, Cold Multi-Symptom (Daytime), Theraflu Warming Relief Daytime Multi-Symptom Cold Caplets, Theraflu Warming Relief Daytime Severe Cold & Cough, Tylenol Cold Head Congestion Daytime, Sudafed PE Pressure+Pain+Cough, Flu & Severe Cold & Cough Daytime Powder, Theraflu ExpressMax Daytime Severe Cold & Cough)
  • Afrin (oxymetazoline nasal)
  • Allergy Relief Tablets (loratadine)
  • Aspirin Low Strength (aspirin)
  • Benadryl Allergy (diphenhydramine)
  • doxylamine (Unisom SleepTabs, Sleep Aid, Equate Sleep Aid, Nytol Maximum Strength, Fast Sleep, Nighttime Sleepaid, Care One Sleep Aid, Doxytex, Aldex AN Chewable, Aldex AN, Equaline Sleep Aid, Medi-Sleep)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Gentle Laxative (bisacodyl)
  • guaifenesin / phenylephrine (Deconex, Gilphex TR, Maxiphen, Entex LA, Refenesen Chest Congestion Relief PE, Mucus Relief Sinus, D-Phen 1000, MontePhen, Mydex, Mucinex Children's Stuffy Nose & Cold, Visonex, D-Tab, Chest Congestion Relief PE, Sinupan, Prolex D, Crantex, Amitex LA, Crantex ER, Pendex, Nasex, Duratuss, Despec, Xpect-PE, Guaiphen-D 600, Guaiphen-D 1200, Donatussin Drops, Simuc, Zotex GPX, Duomax, Guaifen PE, Norel EX, Aldex G, Nexphen PD, Reluri, Nariz, Duraphen 1000, Lusonex, Dynex LA, Miraphen PE, Sudex, Extendryl G, Rescon-GG, Guaphenyl LA, Gentex LA, Xedec II, Liquibid-D, Simuc-GP, Zotex-GP, Triaminic Chest & Nasal Congestion, Duratuss PE, Sitrex PD, Medent-PE, Genexa LA, Nazarin, Ambi 40/1000, J-Max, Medent-PEI, Deconex IR, Guiadex PD, Guiatex PE, Entex LQ, Aquatab D, Respa-PE, Sudafed PE Non-Drying Sinus, Liquibid D-R, Liquibid PD-R, Relcof IR, Lusair, ExeTuss, ExeTuss-GP, MucaphEd, Fenesin PE IR, Reese Onetab Congestion & Cough, Nu-COPD, Supress-PE, Dimetapp Children's Cold & Chest Congestion, Zyrphen, PE-Guai, Tussi-Pres PE, Deconsal Pediatric, Mucus Relief PE, Efasin, Amidal, Chemdal, Quindal, Endal, SINUvent PE, Crantex LA Capsules, Entex ER, Duraphen II, Liquibid-PD, Liquibid-D 1200, Phenavent LA, Quintex, Phenavent D, Deconsal II, Guaifed Caps, Guaifed PD, Sina-12X, Phenavent, Tussbid, Phenavent PED, Nescon-PD, Prolex PD, Aldex, Duravent PE, Crantex LA Tablets, ED Bron GP, Duratuss GP, Sitrex, Guaiphen-PD, Wellbid-D, Wellbid-D 1200, Xedec, Nasex-G)
  • Mucinex DM (dextromethorphan / guaifenesin)
  • Neocitran Non Drowsy Extra Strength Cold and Flu (acetaminophen / dextromethorphan / phenylephrine)
  • phenylephrine (Neo-Synephrine, Sudafed PE Congestion, Phenyl-T, Nasal Decongestant PE, Congest Aid II, Nasop, Vazculep, Suphedrine PE, Help I Have A Stuffy Nose, Despec-SF, Sudogest PE, Nasop12, Triaminic Thin Strips Cold with Stuffy Nose, Dimetapp Toddler's Drops Decongestant, AH-Chew D, Gilchew IR, Little Colds Decongestant, Lusonal, Contac-D, Ricobid-D, PediaCare Children's Decongestant, Sudafed PE Children's Nasal Decongestant)
  • Vitamin C (ascorbic acid)
  • Vitamin C with Rose Hips (ascorbic acid)
  • Vitamin D3 (cholecalciferol)

acetaminophen / dextromethorphan alcohol/food Interactions

There is 1 alcohol/food interaction with acetaminophen / dextromethorphan

acetaminophen / dextromethorphan disease Interactions

There are 4 disease interactions with acetaminophen / dextromethorphan which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.