Acetaminophen / Dextromethorphan Dosage

Medically reviewed by Drugs.com. Last updated on May 21, 2025.

Usual Adult Dose for Cold Symptoms

Acetaminophen-dextromethorphan 1000 mg-30 mg/30 mL oral liquid:
30 mL orally every 6 hours not to exceed 120 mL daily.

Acetaminophen-dextromethorphan 325 mg- 5 mg oral capsule:
1 to 2 capsules orally every 6 hours not to exceed 8 capsules daily.

Usual Adult Dose for Cough

Acetaminophen-dextromethorphan 1000 mg-30 mg/30 mL oral liquid:
30 mL orally every 6 hours not to exceed 120 mL daily.

Acetaminophen-dextromethorphan 325 mg- 5 mg oral capsule:
1 to 2 capsules orally every 6 hours not to exceed 8 capsules daily.

Usual Adult Dose for Pain

Acetaminophen-dextromethorphan 1000 mg-30 mg/30 mL oral liquid:
30 mL orally every 6 hours not to exceed 120 mL daily.

Acetaminophen-dextromethorphan 325 mg- 5 mg oral capsule:
1 to 2 capsules orally every 6 hours not to exceed 8 capsules daily.

Usual Pediatric Dose for Cold Symptoms

Acetaminophen-dextromethorphan 1000 mg-30 mg/30 mL oral liquid:
12 years or older: 30 mL orally every 6 hours not to exceed 120 mL daily.

Acetaminophen-dextromethorphan 160 mg-5 mg oral tablet, chewable:
2 to 5 years: 1 tablet orally, chewed or dissolved before swallowing, every 4 hours not to exceed 5 tablets daily.
6 to 12 years: 2 tablets orally, chewed or dissolved before swallowing, every 4 hours not to exceed 10 tablets daily.

Acetaminophen-dextromethorphan 160 mg-5 mg/5 mL oral liquid:
4 to 5 years: 5 mL orally every 4 hours not to exceed 25 mL daily.
6 to 12 years: 10 mL orally every 4 hours not to exceed 50 mL daily.

Acetaminophen-dextromethorphan 160 mg-5 mg/5 mL oral suspension:
2 to 5 years: 5 mL orally every 4 hours not to exceed 25 ml daily.
6 to 12 years: 10 mL orally every 4 hours not to exceed 50 mL daily.

Acetaminophen-dextromethorphan 160 mg-7.5 mg/5 mL oral liquid:
2 to 5 years: 5 mL orally every 6 hours not to exceed 20 mL daily.
6 to 12 years: 10 mL orally every 6 hours not to exceed 40 mL daily.

Acetaminophen-dextromethorphan 325 mg- 5 mg oral capsule:
6 to 11 years: 1 capsule every 6 hours not to exceed 4 capsules daily.
12 years or older: 1 to 2 capsules orally every 6 hours not to exceed 8 capsules daily.

Usual Pediatric Dose for Cough

Acetaminophen-dextromethorphan 1000 mg-30 mg/30 mL oral liquid:
12 years or older: 30 mL orally every 6 hours not to exceed 120 mL daily.

Acetaminophen-dextromethorphan 160 mg-5 mg oral tablet, chewable:
2 to 5 years: 1 tablet orally, chewed or dissolved before swallowing, every 4 hours not to exceed 5 tablets daily.
6 to 12 years: 2 tablets orally, chewed or dissolved before swallowing, every 4 hours not to exceed 10 tablets daily.

Acetaminophen-dextromethorphan 160 mg-5 mg/5 mL oral liquid:
4 to 5 years: 5 mL orally every 4 hours not to exceed 25 mL daily.
6 to 12 years: 10 mL orally every 4 hours not to exceed 50 mL daily.

Acetaminophen-dextromethorphan 160 mg-5 mg/5 mL oral suspension:
2 to 5 years: 5 mL orally every 4 hours not to exceed 25 ml daily.
6 to 12 years: 10 mL orally every 4 hours not to exceed 50 mL daily.

Acetaminophen-dextromethorphan 160 mg-7.5 mg/5 mL oral liquid:
2 to 5 years: 5 mL orally every 6 hours not to exceed 20 mL daily.
6 to 12 years: 10 mL orally every 6 hours not to exceed 40 mL daily.

Acetaminophen-dextromethorphan 325 mg- 5 mg oral capsule:
6 to 11 years: 1 capsule every 6 hours not to exceed 4 capsules daily.
12 years or older: 1 to 2 capsules orally every 6 hours not to exceed 8 capsules daily.

Usual Pediatric Dose for Pain

Acetaminophen-dextromethorphan 1000 mg-30 mg/30 mL oral liquid:
12 years or older: 30 mL orally every 6 hours not to exceed 120 mL daily.

Acetaminophen-dextromethorphan 160 mg-5 mg oral tablet, chewable:
2 to 5 years: 1 tablet orally, chewed or dissolved before swallowing, every 4 hours not to exceed 5 tablets daily.
6 to 12 years: 2 tablets orally, chewed or dissolved before swallowing, every 4 hours not to exceed 10 tablets daily.

Acetaminophen-dextromethorphan 160 mg-5 mg/5 mL oral liquid:
4 to 5 years: 5 mL orally every 4 hours not to exceed 25 mL daily.
6 to 12 years: 10 mL orally every 4 hours not to exceed 50 mL daily.

Acetaminophen-dextromethorphan 160 mg-5 mg/5 mL oral suspension:
2 to 5 years: 5 mL orally every 4 hours not to exceed 25 ml daily.
6 to 12 years: 10 mL orally every 4 hours not to exceed 50 mL daily.

Acetaminophen-dextromethorphan 160 mg-7.5 mg/5 mL oral liquid:
2 to 5 years: 5 mL orally every 6 hours not to exceed 20 mL daily.
6 to 12 years: 10 mL orally every 6 hours not to exceed 40 mL daily.

Acetaminophen-dextromethorphan 325 mg- 5 mg oral capsule:
6 to 11 years: 1 capsule every 6 hours not to exceed 4 capsules daily.
12 years or older: 1 to 2 capsules orally every 6 hours not to exceed 8 capsules daily.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution in patients with liver disease. Chronic use of acetaminophen is not recommended in patients with liver disease.

Precautions

Patients who consume three or more alcohol containing drinks per day should be informed to consult with their physician for advice on when and how to take acetaminophen. Chronic, heavy alcohol users may be at increased risk of liver damage when taking more than recommended dosages.

Patients and adults taking care of children should be advised to consult with their doctor before continuing to use acetaminophen if symptoms of illness worsen. Although rare, there is the possibility of acetaminophen intoxication on chronic use of the drug, and the symptoms seen during the first phase of intoxication (nausea, vomiting, anorexia, malaise, and diaphoresis) may trigger the use of more doses.

Dialysis

Data not available

Other Comments

Do not crush or chew extended release products.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer