Acetaminophen/dextromethorphan Drug Interactions
Currently displaying a list of 488 drugs known to interact with acetaminophen / dextromethorphan.
- 86 major drug interactions
- 374 moderate drug interactions
- 28 minor drug interactions
Medications known to interact with acetaminophen/dextromethorphan
Note: Showing generic names only.
- abametapir topical
- abiraterone
- acetylcarbromal
- acrivastine
- adagrasib
- adalimumab
- alefacept
- alfentanil
- allopurinol
- almotriptan
- alprazolam
- amiodarone
- amisulpride
- amitriptyline
- amobarbital
- amoxapine
- amphetamine
- anagrelide
- anakinra
- anisindione
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aripiprazole
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atezolizumab
- atropine
- avelumab
- azatadine
- azelastine nasal
- baclofen
- bedaquiline
- belladonna
- benoxinate ophthalmic
- benzocaine topical
- benzphetamine
- benztropine
- berotralstat
- bimekizumab
- biperiden
- black cohosh
- brentuximab
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
- calaspargase pegol
- canakinumab
- cannabidiol
- cannabis
- capivasertib
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- charcoal
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- cholestyramine
- cimetidine
- cinacalcet
- citalopram
- clemastine
- clidinium
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- codeine
- cosibelimab
- cyclizine
- cyclobenzaprine
- cyproheptadine
- daclizumab
- dacomitinib
- danicopan
- dantrolene
- daridorexant
- darifenacin
- deferasirox
- delavirdine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dextroamphetamine
- dezocine
- diazepam
- dibucaine topical
- dicumarol
- dicyclomine
- difelikefalin
- diflunisal
- dihydroergotamine
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- dolasetron
- dostarlimab
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
- durvalumab
- echinacea
- efavirenz
- elacestrant
- eletriptan
- eliglustat
- emapalumab
- encorafenib
- entacapone
- epcoritamab
- epirubicin
- ergotamine
- escitalopram
- esketamine
- eslicarbazepine
- estazolam
- eszopiclone
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etranacogene dezaparvovec
- ezogabine
- fedratinib
- felbamate
- fenfluramine
- fenofibrate
- fenoldopam
- fentanyl
- fexinidazole
- fidanacogene elaparvovec
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosphenytoin
- fostamatinib
- frovatriptan
- furazolidone
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gepirone
- givosiran
- glofitamab
- glycerol phenylbutyrate
- glycopyrrolate
- golimumab
- granisetron
- guanfacine
- guselkumab
- halazepam
- halofantrine
- haloperidol
- heroin
- hydrocodone
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
- idelalisib
- iloperidone
- imatinib
- imipramine
- infliximab
- interferon beta-1a
- interferon beta-1b
- ipilimumab
- isocarboxazid
- isoniazid
- lamotrigine
- lasmiditan
- leflunomide
- lemborexant
- lenacapavir
- leniolisib
- levetiracetam
- levobupivacaine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linezolid
- liraglutide
- lisdexamfetamine
- lithium
- lofexidine
- lomitapide
- lonapegsomatropin
- lorazepam
- lorcaserin
- lorlatinib
- loxapine
- lumateperone
- lurasidone
- maprotiline
- mavorixafor
- mazindol
- meclizine
- melatonin
- memantine
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methscopolamine
- methsuximide
- methyldopa
- methylene blue
- metoclopramide
- metyrosine
- mibefradil
- midazolam
- milnacipran
- mipomersen
- mirabegron
- mirtazapine
- mitotane
- molindone
- morphine
- morphine liposomal
- nabilone
- nalbuphine
- naltrexone
- naratriptan
- nefazodone
- nemolizumab
- nicotine
- nilotinib
- niraparib
- nivolumab
- nortriptyline
- olanzapine
- oliceridine
- olutasidenib
- omaveloxolone
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- ospemifene
- oxamniquine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- ozanimod
- paliperidone
- palonosetron
- panobinostat
- paraldehyde
- paramethadione
- paroxetine
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phentermine
- phenytoin
- pimozide
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- pralsetinib
- pramipexole
- pramoxine topical
- pregabalin
- pretomanid
- primidone
- probenecid
- procaine
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propantheline
- proparacaine ophthalmic
- propiomazine
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
- ramelteon
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- remdesivir
- remifentanil
- remimazolam
- retifanlimab
- rifampin
- rilonacept
- risperidone
- ritlecitinib
- ritonavir
- rizatriptan
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
- safinamide
- sarilumab
- satralizumab
- scopolamine
- secobarbital
- secukinumab
- selegiline
- sertraline
- sibutramine
- siltuximab
- sodium salicylate
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- st. john's wort
- stiripentol
- sufentanil
- sulfinpyrazone
- sumatriptan
- suvorexant
- tafamidis
- tapentadol
- tarlatamab
- tasimelteon
- tebentafusp
- teclistamab
- tedizolid
- temazepam
- terbinafine
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticlopidine
- tislelizumab
- tizanidine
- tocilizumab
- tolcapone
- tolterodine
- topiramate
- toripalimab
- trabectedin
- tramadol
- tranylcypromine
- trazodone
- tremelimumab
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- troglitazone
- trospium
- tryptophan
- valbenazine
- valdecoxib
- valerian
- valoctocogene roxaparvovec
- valproic acid
- varenicline
- vemurafenib
- venlafaxine
- vigabatrin
- vilazodone
- viloxazine
- vimseltinib
- vortioxetine
Acetaminophen/dextromethorphan alcohol/food interactions
There is 1 alcohol/food interaction with acetaminophen / dextromethorphan.
Acetaminophen/dextromethorphan disease interactions
There are 3 disease interactions with acetaminophen / dextromethorphan which include:
More about acetaminophen / dextromethorphan
- acetaminophen/dextromethorphan consumer information
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Diphenhydramine
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Benadryl
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Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Mucinex
Mucinex (guaifenesin) is used to relieve the symptoms of cough and loosen mucus in the chest ...
Norco
Norco (acetaminophen and hydrocodone) is used to relieve moderate to severe pain. Includes Norco ...
Promethazine DM
Promethazine DM is used for allergic rhinitis, cold symptoms, cough
Banophen
Banophen is used for allergic reactions, allergic rhinitis, cold symptoms, cough, extrapyramidal ...
Benadryl Allergy
Benadryl Allergy is used for allergic reactions, allergic rhinitis, allergies, cold symptoms ...
Echinacea
Echinacea systemic is used for cold symptoms, condylomata acuminata, herbal supplementation
Acetaminophen/hydrocodone
The combination of hydrocodone and acetaminophen is used to relieve moderate to severe pain ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.