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Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) Drug Interactions

A total of 925 drugs are known to interact with Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine).

  • 269 major drug interactions
  • 618 moderate drug interactions
  • 38 minor drug interactions

Show all medications in the database that may interact with Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine).

Check for interactions with Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)

  • albuterol (Ventolin, ProAir HFA, Ventolin HFA, Proventil, Proventil HFA, ProAir RespiClick, Respirol, AccuNeb, Vospire ER, Airet, Volmax, ProAir Digihaler)
  • Aleve (naproxen)
  • baclofen (Lioresal, Gablofen, Kemstro, Lioresal Intrathecal)
  • Benadryl (diphenhydramine)
  • cyclobenzaprine (Flexeril, Amrix, Fexmid, Comfort Pac with Cyclobenzaprine)
  • Cymbalta (duloxetine)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Unisom SleepGels, Dicopanol, Sleep, Diphenhist, Sominex, Diphen, Diphenadryl, Benadryl Children's Allergy, Allermax, Diphenydramine Quick Melt, Nytol, Diphedryl, Hydramine, Diphendryl, Pharbedryl, Buckley's Bedtime, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen Cough, DPH, Allergia-C, Q-Dryl, Sleep Tabs, Quenalin, Sleep-ettes D, Q-Dryl A/F, Dytan, Vanamine PD, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, 40 Winks, Diphen AF, Aler-Dryl, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Aller-G-Time, Sleep Tab II, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Diphenyl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Uni-Tann, Diphenmax, Nightime Sleepaid, Ben-Tann, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, Unisom SleepMelts, PediaCare Children's Allergy, Truxadryl, Simply Sleep, Complete Allergy Relief, Dytuss, Dormin, Miles Nervine, Scot-Tussin Allergy)
  • Excedrin Migraine (acetaminophen / aspirin / caffeine)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Proprinal, Motrin IB, Children's Motrin, IBU-200, Advil Migraine, Ibu-8, Motrin Childrens, Nuprin, Motrin Migraine Pain, Ibuprofen PMR, NeoProfen, Caldolor, Advil Children's, Addaprin, Motrin Infant Drops, Advil Infant's Concentrated Drops, Rufen, Genpril, A-G Profen, Ibu-Tab, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, Childrens Ibuprofen Berry, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Allergy Relief Tablets, Claritin Reditabs, Wal-itin, Loratadine Reditab, Children's Claritin Allergy, Allergy Relief 24 Hour, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, Help I Have Allergies, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Anaprox-DS, Naprelan, EC-Naprosyn, Flanax Pain Reliever, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • Norco (acetaminophen / hydrocodone)
  • promethazine (Phenergan, Promethegan, Phenadoz, Antinaus 50, Anergan 50, Adgan, Phenazine 50, Phenergan Fortis, V-Gan-50, V-Gan-25, Phenoject-50, Pro-Med)
  • ranitidine (Zantac, Zantac 150, Zantac 75, Zantac 300, Deprizine, Zantac Injection, Acid Reducer, Zantac 150 EFFERdose, Taladine, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Acid Relief, Sunmark Acid Reducer Maximum Strength, Acid Control 75, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • Tylenol (acetaminophen)
  • Tylenol Extra Strength (acetaminophen)
  • Vicks NyQuil Cold & Flu Nighttime Relief (acetaminophen / dextromethorphan / doxylamine)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)

Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) alcohol/food interactions

There is 1 alcohol/food interaction with Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)

Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) disease interactions

There are 8 disease interactions with Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine) which include:

More about Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)

Related treatment guides

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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