Tylenol Drug Interactions
Currently displaying a list of 159 drugs known to interact with Tylenol (acetaminophen).
- 8 major drug interactions
- 115 moderate drug interactions
- 36 minor drug interactions
Medications known to interact with Tylenol
Note: Showing generic names only.
- amobarbital
- anagrelide
- anisindione
- apalutamide
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atezolizumab
- atropine
- avelumab
- bedaquiline
- belladonna
- benoxinate ophthalmic
- benzocaine topical
- benztropine
- biperiden
- black cohosh
- brentuximab
- bupivacaine
- bupivacaine liposome
- bupropion
- busulfan
- butabarbital
- butalbital
- calaspargase pegol
- cannabidiol
- carbamazepine
- cemiplimab
- ceritinib
- charcoal
- chloroprocaine
- chloroprocaine ophthalmic
- cholestyramine
- cimetidine
- clidinium
- clofarabine
- cocaine nasal
- cocaine topical
- cosibelimab
- daclizumab
- darifenacin
- deferasirox
- dibucaine topical
- dicumarol
- dicyclomine
- diflunisal
- dostarlimab
- durvalumab
- echinacea
- efavirenz
- encorafenib
- epirubicin
- ethanol
- ethinyl estradiol
- ethotoin
- etidocaine
- etranacogene dezaparvovec
- leflunomide
- leniolisib
- levobupivacaine
- levoketoconazole
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- liraglutide
- lomitapide
- lorlatinib
- mavorixafor
- mepenzolate
- mephenytoin
- mephobarbital
- mepivacaine
- methohexital
- methotrexate
- methscopolamine
- metoclopramide
- mipomersen
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- pentobarbital
- pexidartinib
- phenobarbital
- phenytoin
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- pralsetinib
- pramoxine topical
- primidone
- probenecid
- procaine
- procyclidine
- propantheline
- proparacaine ophthalmic
- propranolol
- ranitidine
- ranitidine bismuth citrate
- remdesivir
- retifanlimab
- rifampin
- ritlecitinib
- ropivacaine
- rucaparib
- tafamidis
- teriflunomide
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thioguanine
- thiopental
- tislelizumab
- tolterodine
- toripalimab
- trabectedin
- tremelimumab
- trihexyphenidyl
- trospium
Tylenol alcohol/food interactions
There are 2 alcohol/food interactions with Tylenol (acetaminophen).
Tylenol disease interactions
There are 3 disease interactions with Tylenol (acetaminophen) which include:
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- Drug class: miscellaneous analgesics
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
