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Zegerid with Magnesium Hydroxide Dosage

Medically reviewed by Last updated on May 31, 2021.

Generic name: omeprazole, sodium bicarbonate and magnesium hydroxide
Dosage form: tablet, chewable

ZEGERID with Magnesium Hydroxide (omeprazole/sodium bicarbonate/magnesium hydroxide) is available as chewable tablets in 20 mg and 40 mg strengths for adult use. Directions for use for each indication are summarized in Table 13.

Because ZEGERID chewable tablets contain magnesium hydroxide, the chewable tablets should not be substituted for other dosage forms (eg, ZEGERID Powder for Oral Suspension or ZEGERID Capsules).

Since both the 20-mg and 40-mg chewable tablets contain the same amount of sodium bicarbonate (600 mg) and magnesium hydroxide (700 mg), two 20-mg chewable tablets are not equivalent to one 40-mg chewable tablet; therefore, two 20-mg chewable tablets should not be substituted for one 40-mg chewable tablet.

ZEGERID with Magnesium Hydroxide should be taken on an empty stomach at least one hour before a meal.

Table 13: Recommended Doses of ZEGERID® with Magnesium Hydroxide by Indication for Adults 18 Years and Older
Indication Recommended Dose Frequency

* Most patients heal within 4 weeks. Some patients may require an additional 4 weeks of therapy.

** For additional information, see CLINICAL PHARMACOLOGY, Clinical Studies section

+ For additional information, see INDICATIONS AND USAGE section

Short-Term Treatment of Active
Duodenal Ulcer
20 mg Once daily for 4 weeks*,+
Benign Gastric Ulcer 40 mg Once daily for 4-8 weeks **,+
Gastroesophageal Reflux Disease (GERD)

Symptomatic GERD
(with no esophageal erosions)
20 mg Once daily for up to 4 weeks+

Erosive Esophagitis 20 mg Once daily for 4-8 weeks+
Maintenance of Healing of Erosive Esophagitis 20 mg Once daily**

Administration of Chewable Tablets

ZEGERID with Magnesium Hydroxide chewable tablets should be chewed and swallowed with water. DO NOT SWALLOW WHOLE. DO NOT USE OTHER LIQUIDS. DO NOT SUBSTITUTE FOR OTHER ZEGERID DOSAGE FORMS.

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