Zafirlukast Dosage

Usual Adult Dose for Asthma - Maintenance

-20 mg orally twice a day, 1 hour before or 2 hours after meals

Comments:
-A dose of 20 mg twice daily was not associated with an increase in the overall incidence of adverse events or withdrawals in elderly patients.

Use: Prophylaxis and chronic treatment of asthma

Usual Pediatric Dose for Asthma - Maintenance

Less than 5 years: The safety and effectiveness has not been established.

5 to 11 years:
-10 mg orally twice a day, 1 hour before or 2 hours after meals

12 years or older:
-20 mg orally twice a day, 1 hour before or 2 hours after meals

Use: Prophylaxis and chronic treatment of asthma

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Hepatic impairment including cirrhosis: Contraindicated

This drug has not been evaluated in patients with hepatitis or in long-term studies of patients with cirrhosis.

Precautions

Safety and efficacy have not been established in patients younger than 5 years.

Consult WARNINGS section for additional precautions.

Dialysis

No data available

Other Comments

Administration advice:
-This drug should be taken at least 1 hour before or 2 hours after meals.
-Ongoing clinical assessment, including diagnostic evaluations and treatment is recommended.

Storage requirements:
-Store at controlled room temperature, 20C to 25C (68F to 77F).
-Protect from light and moisture.

General:
-This drug is not a bronchodilator and should not be used to treat acute episodes of asthma.

Patient advice:
-Report immediately any symptoms of hepatic dysfunction (e.g., right upper quadrant abdominal pain, nausea, fatigue, lethargy, pruritus, jaundice, flu-like symptoms, and anorexia).
-This drug is indicated for the chronic treatment of asthma and should be taken regularly as prescribed, even during symptom-free periods.
-Patients should not decrease the dose of this drug or stop taking any other antiasthma medications unless instructed by a physician.
-Notify the physician if neuropsychiatric events occur while using this drug.