Xifyrm Dosage

Use for the shortest duration consistent with individual patient treatment goals.
For intravenous administration only.
The recommended dosage of XIFYRM is 30 mg once daily, administered by intravenous bolus injection over 15 seconds.
When initiating XIFYRM, monitor patient analgesic response. Because the median time to meaningful pain relief was 2 and 3 hours after XIFYRM administration in two clinical studies, a non-NSAID analgesic with a rapid onset of effect may be needed, for example, upon anesthetic emergence or resolution of local or regional anesthetic blocks.
Some patients may not experience adequate analgesia for the entire 24-hour dosing interval and may require administration of a short-acting, non-NSAID, immediate-release analgesic.
To reduce the risk of renal toxicity, patients must be well hydrated prior to administration of XIFYRM.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration. Should the contents appear discolored or contain particulate matter, discard the vial.