Tribenzor Dosage
Generic name: OLMESARTAN MEDOXOMIL 20mg, AMLODIPINE BESYLATE 5mg, HYDROCHLOROTHIAZIDE 12.5mg
Dosage form: tablet, film coated
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General Considerations
Dose once daily.
Dosage may be increased after 2 weeks. The full blood pressure lowering effects are attained within 2 weeks after a change in dose. The maximum recommended dose of Tribenzor is 40/10/25 mg. Tribenzor may be taken with or without food.
Tribenzor may be administered with other antihypertensive agents.
Renal Impairment
The usual regimens of therapy with Tribenzor may be followed if the patient’s creatinine clearance is >30 mL/min. In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so avoid use of Tribenzor [see Warnings and Precautions (5.4)].
Elderly
Patients ≥ 75 years of age should start amlodipine at 2.5 mg, which is not available with Tribenzor.
Hepatic Impairment
Patients with severe hepatic impairment should start amlodipine at 2.5 mg, which is not available with Tribenzor [see Warnings and Precautions (5.5)].
Replacement Therapy
Tribenzor may be substituted for its individually titrated components.
Add-on/Switch Therapy
Tribenzor may be used to provide additional blood pressure lowering for patients not adequately controlled on maximally tolerated, labeled, or usual doses of any two of the following antihypertensive classes: angiotensin receptor blockers (ARB), calcium channel blockers (CCB), and diuretics.
A patient who experiences dose-limiting adverse reactions to an individual component while on any dual combination of the components of Tribenzor may be switched to Tribenzor containing a lower dose of that component to achieve similar blood pressure reductions.
