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Triazolam Dosage

Medically reviewed on September 28, 2018.

Applies to the following strengths: 0.125 mg; 0.25 mg

Usual Adult Dose for:

Usual Geriatric Dose for:

Additional dosage information:

Usual Adult Dose for Insomnia

Initial dose: 0.25 mg orally once a day at bedtime
Maintenance dose: 0.125 to 0.25 mg orally once a day at bedtime
Maximum dose: 0.5 mg/day
Duration of therapy: 7 to 10 days

Comments:
-Failure to respond after 7 to 10 days may suggest a primary psychiatric and/or medical illness that requires further evaluation.
-Use of this drug for more than 2 to 3 weeks requires complete reevaluation of the patient.

Use: Short-term treatment of insomnia

Usual Geriatric Dose for Insomnia

Initial dose: 0.125 mg orally once a day at bedtime
Maintenance dose: 0.125 to 0.25 mg orally once a day at bedtime
Maximum dose: 0.25 mg/day
Duration of therapy: 7 to 10 days

Comments:
-Failure to respond after 7 to 10 days may suggest a primary psychiatric and/or medical illness that requires further evaluation.
-Use of this drug for more than 2 to 3 weeks requires complete reevaluation of the patient.
-The lowest effective dose should be used to minimize the potential for oversedation.

Use: Short-term treatment of insomnia

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Dose Adjustments

Debilitated patients or patients with low body weight:
-Initial dose: 0.125 mg orally once a day at bedtime
-Maintenance dose: 0.125 to 0.25 mg orally once a day at bedtime
-Maximum dose: 0.25 mg/day

Treatment withdrawal:
-Treatment should not be abruptly ceased, particularly in patients with a history of seizure.
-Tapering of the dose is recommended in any patient taking more than the lowest dose for longer than a few weeks.

Precautions

US BOXED WARNINGS:
RISKS FROM CONCOMITANT USE WITH OPIOIDS:
-Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.
-Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.
-Limit dosages and durations to the minimum required.
-Follow patients for signs and symptoms of respiratory depression and sedation.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration advice:
-Doses should be administered immediately before bedtime.
-Doses should not be taken where a full night's sleep and clearance of the drug from the body are not possible before the patient would need to be active and functional, e.g., overnight flights lasting less than 7 to 8 hours.

General:
-Prescriptions for this drug should be written for short-term use; it should not be prescribed in quantities that exceed a 1-month supply.
-The elderly are more susceptible to dose-related side effects such as drowsiness, dizziness, lightheadedness, and amnesia.
-The lowest effective dose should be used.

Monitoring:
-Nervous system: Anterograde amnesia, drowsiness, dizziness
-Other: Withdrawal side effects, e.g., rebound insomnia, tolerance, dependence
-Psychiatric: Complex behaviors such as "sleep-driving", anxiety, emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.

Patient advice:
-Tell your healthcare provider about all of the medicines that you take, including prescription and non-prescription medicines.
-This medicine may cause drowsiness and dizziness and reduce alertness; do not drive a car or operate dangerous machinery until you know how this drug affects you.
-You may still be dizzy or drowsy the day after taking this medicine; take care as a pedestrian
-Do not drink alcohol or take other medicines that may cause sleepiness or dizziness while taking this medicine until you talk to your healthcare provider.
-Do not stop taking this medicine suddenly without first consulting your doctor.
-After taking this medicine, you may get up out of bed while not being fully awake, do an activity that you do not know you are doing, and the next morning, you may not remember that you did anything during the night. Reported activities include driving a car, making and eating food, talking on the phone, and sleep-walking. There is a greater chance of this happening if you drink alcohol or take other medicines that make you sleepy while you are taking this medicine. Contact your doctor as soon as possible if any of this occurs.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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