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Triazolam Pregnancy and Breastfeeding Warnings

Triazolam is also known as: Halcion

Medically reviewed on Sep 28, 2018

Triazolam Pregnancy Warnings

Animal studies have shown evidence of retarded or impaired skeletal formation, and impaired viability and weight gain. There are no controlled data in human pregnancy.

Benzodiazepines cross the placenta and may cause hypotonia, respiratory depression, and hypothermia in the newborn infant. Withdrawal symptoms in newborn infants have been reported with this class of drug. Also, neonatal flaccidity has been reported in an infant born of a mother who had been receiving benzodiazepines.

AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details.

US FDA pregnancy category X: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Use is contraindicated

AU TGA pregnancy category: C
US FDA pregnancy category: X

See references

Triazolam Breastfeeding Warnings

Use should be avoided.
-Some experts recommend: Use is contraindicated.

Excreted into human milk: Unknown
Excreted into animal milk: Yes

Comment: The American Academy of Pediatrics considers similarly acting drugs agents that may be of concern during breastfeeding.

Little information is available on the use of this drug during breastfeeding; an alternate short-acting hypnotic may be preferred (e.g., oxazepam or lorazepam), particularly when nursing a newborn or preterm infant. Because of its relatively short half-life, occasional use during breastfeeding in an older infant should pose little risk; however, the infant should be monitored for excessive drowsiness.

See references

References for pregnancy information

  1. "Product Information. Halcion (triazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
  2. Cerner Multum, Inc. "Australian Product Information." O 0

References for breastfeeding information

  1. Cerner Multum, Inc. "Australian Product Information." O 0
  2. "Product Information. Halcion (triazolam)." Pharmacia and Upjohn, Kalamazoo, MI.
  3. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  4. Department of Adolescent and Child Health and Development. UNICEF. World Health Organization "Breastfeeding and maternal medication: recommendations for drugs in the eleventh Who model list of essential drugs. Available from: URL: http://whqlibdoc.who.int/hq/2002/55732.pdf?ua=1" ([2003]):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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