Medically reviewed by Drugs.com. Last updated on April 28, 2021.
Applies to the following strengths: 20 mg; 40 mg; 80 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 40 mg orally once a day
Maintenance dose: 40 to 80 mg orally once a day
Comments: Most of the antihypertensive effect is present within 2 weeks; maximum blood pressure reduction at a given dose is generally observed within 4 weeks of starting that dose.
Usual Adult Dose for Cardiovascular Risk Reduction
80 mg orally once a day
-It is unknown whether doses lower than 80 mg are effective in reducing the risk of cardiovascular morbidity and mortality.
-When initiating this drug for cardiovascular risk reduction, monitoring of blood pressure is recommended, and if appropriate, adjustment of other medications that lower blood pressure.
Use: Reduction of risk of myocardial infarction, stroke, or death from cardiovascular causes in patients 55 years or older at high risk of developing major cardiovascular events who are unable to take angiotensin-converting enzyme (ACE) inhibitors. High risk for cardiovascular events can be evidenced by a history of coronary artery disease, peripheral arterial disease, stroke, transient ischemic attack, or high-risk diabetes (insulin-dependent or non-insulin dependent) with evidence of end-organ damage.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
Initiate at low doses and titrate slowly
US BOXED WARNING:
-FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin angiotensin system (RAS) can cause injury and death to the developing fetus.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Hemodialysis: No adjustment recommended
Peritoneal dialysis: Data not available
Monitoring: Monitor serum electrolytes periodically.
Patient advice: Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.
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