Tekturna HCT Dosage
Generic name: ALISKIREN HEMIFUMARATE 150mg, HYDROCHLOROTHIAZIDE 12.5mg
Dosage form: tablet, film coated
Drug class: Miscellaneous antihypertensive combinations
Medically reviewed by Drugs.com. Last updated on Nov 6, 2024.
Dose Selection
The recommended once-daily doses of Tekturna HCT in order of increasing mean effect are 150/12.5 mg, 150/25 mg or 300/12.5 mg, and 300/25 mg.
Dose Titration
The antihypertensive effect of Tekturna HCT is largely manifested within 1 week, with maximal effects generally seen at around 4 weeks. If blood pressure remains uncontrolled after 2 to 4 weeks of therapy, the dose may be titrated up to a maximum of aliskiren 300 mg/HCTZ 25 mg.
Add-On Therapy
A patient whose blood pressure is not adequately controlled with aliskiren alone or hydrochlorothiazide alone may be switched to combination therapy with Tekturna HCT. The usual recommended starting dose is 150/12.5 mg once daily as needed to control blood pressure. The dose may be titrated up to a maximum of aliskiren 300 mg/hydrochlorothiazide 25 mg once daily.
Initial Therapy
The usual recommended starting dose is 150/12.5 mg once daily as needed to control blood pressure. The dose may be titrated up to a maximum of aliskiren 300 mg/HCTZ 25 mg once daily.
Tekturna HCT is not recommended for use as initial therapy in patients with intravascular volume depletion [ see Warnings and Precautions ( 5.4) ].
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