Skip to main content

Saxagliptin Dosage

Medically reviewed by Last updated on May 12, 2023.

Applies to the following strengths: 2.5 mg; 5 mg

Usual Adult Dose for Diabetes Type 2

2.5 or 5 mg orally once a day, regardless of meals

Coadministration with strong CYP450 3A4/5 inhibitors: 2.5 mg orally once a day

Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes in multiple clinical settings

Renal Dose Adjustments

Mild renal dysfunction (CrCl more than 50 mL/min): No adjustment recommended.
Moderate or severe renal dysfunction (CrCl 50 mL/min or less): 2.5 mg orally once a day, regardless of meals

Liver Dose Adjustments

No adjustment recommended.

Dose Adjustments

Concomitant use with an insulin secretagogue or with insulin: A lower dose of insulin secretagogue or insulin may be required to minimize the risk of hypoglycemia.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Hemodialysis: 2.5 mg following hemodialysis
Peritoneal dialysis: Data not available

Other Comments

Administration advice:



Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.