Applies to the following strength(s): 200 mg400 mg40 mg/mL
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Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Lennox-Gastaut Syndrome
Initial dose: 400 to 800 mg orally per day administered in 2 equally divided doses in the morning and evening
The dose should be increased by 400 to 800 mg per day every 2 days until a maximum daily dose of 3200 mg/day, administered in 2 equally divided doses is reached. It is not known whether doses lower than 3200 mg are effective.
Use: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome in pediatric patients 1 year of age and older and in adults
Usual Pediatric Dose for Lennox-Gastaut Syndrome
1 year of age and older:
Initial dose: 10 mg/kg/day orally administered in 2 equally divided doses in the morning and evening
The dose should be increased by approximately 10 mg/kg every other day to a target dose of 45 mg/kg/day or 3200 mg/day, whichever is less, administered in 2 equally divided doses. It is not known whether doses lower than the target dose are effective.
Use: For adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome in pediatric patients 1 year of age and older
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
Mild (Child-Pugh 5 to 6) to moderate (Child-Pugh 7 to 9): Caution recommended
Severe hepatic impairment (Child-Pugh 10 to 15): Not recommended
This drug should be withdrawn gradually to reduce the possibility of seizures. In studies discontinuation was achieved by reducing the dose by approximately 25% every 2 days.
Safety and efficacy have not been established in patients younger than 1 year.
Consult WARNINGS section for additional precautions.
Hemodialysis reduces plasma levels of this drug by about 30%. Dose adjustments should be considered in patients undergoing dialysis.
-This drug can be administered whole, cut in half, or crushed and dissolved in a half glass of water.
-This drug should be taken with water.
-Shake the oral suspension well before every administration.
-This drug should be administered with food.
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