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Reslizumab Dosage

Applies to the following strength(s): 10 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Asthma

3 mg/kg IV over 20 to 50 minutes every 4 weeks

Comments:
-Do not administer as an IV push or bolus.
-The infusion should be discontinued immediately if the patient experiences a severe systemic reaction, including anaphylaxis.

Use: For the add-on maintenance treatment of patients with severe asthma with an eosinophilic phenotype

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNINGS:
-Anaphylaxis occurred in 0.3% of patients in placebo-controlled studies.
-Patients should be observed for an appropriate period of time after the infusion and healthcare professionals should be prepared to manage anaphylaxis that can be life-threatening.
-Discontinue therapy immediately if the patient experiences anaphylaxis.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug is for IV use only. Do not administer as an IV push or bolus.
-This drug should be administered in a healthcare setting by a healthcare professional prepared to manage anaphylaxis.
-If refrigerated prior to administration, allow the diluted solution to reach room temperature before use.
-Use an infusion set with an in-line, low protein-binding filter (pore size of 0.2 micron). This drug is compatible with polyethersulfone (PES), polyvinylidene fluoride (PVDF), nylon, and cellulose acetate in-line infusion filters.
-The infusion time may vary depending on the total volume to be infused as based upon patient weight.
-Do not infuse this drug concomitantly in the same IV line with other agents. No physical or biochemical compatibility studies have been conducted to evaluate the coadministration of this drug with other agents.
-Observe the patient over the infusion and for an appropriate period of time following infusion.

Storage requirements:
-Consult the manufacturer product information.

Reconstitution/preparation techniques:
-Consult the manufacturer product information.

IV compatibility:
-Consult the manufacturer product information.

General:
-This drug is indicated for treatment of asthma of the eosinophilic phenotype but not for other eosinophilic conditions.
-This drug is not indicated for the relief of acute bronchospasm or status asthmaticus.

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