Ramelteon Dosage

Medically reviewed by Drugs.com. Last updated on Mar 10, 2025.

Usual Adult Dose for Insomnia

8 mg orally within 30 minutes of going to bed

Maximum Dose: 8 mg per day

Comments: This drug should not be taken with or immediately after a high-fat meal.

Use: Treatment of insomnia characterized by difficulty with sleep onset

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

• Mild Hepatic Impairment (Child-Pugh A): Data not available.
• Moderate Hepatic Impairment (Child-Pugh B): Use with caution.
• Severe Hepatic Impairment (Child-Pugh C): Not recommended.

Dose Adjustments

• Concomitant Use of CYP450 1A2 Inhibiting Drugs: Contraindicated with fluvoxamine; Caution recommended if used with other CYP450 1A2 inhibitors.

• Patients with Severe Sleep Apnea: Not recommended.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

• Hemodialysis: No adjustment recommended.
• Peritoneal dialysis: Data not available.

Other Comments

Administration Advice:

• The drug tablet should be swallowed whole; tablets should not be broken.

Storage Requirements:

• The container should be kept tightly closed to protect from moisture and humidity.

General:

• This drug does not appear to produce physical dependence; treatment discontinuation after chronic administration did not produce withdrawal signs in humans or in animals.
• If overdosage occurs, general symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate and IV fluids as needed.

Patient Advice:

• Do not drink alcohol while taking this drug.
• Do not take other medications that can make you sleepy while taking this drug.
• Do not take this drug with food or right after a meal.
• Do not take this drug unless you are able to get a full night's sleep before you must be active again.
• After taking this drug, avoid driving and other activities that require concentration such as operating machinery; limit your activities to those necessary to prepare for bed.
• Consult your healthcare provider if your insomnia worsens or is not better within 7 to 10 days.

Frequently asked questions

• What are the strongest sleeping pills?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer