Ramelteon Dosage

Medically reviewed by Drugs.com. Last updated on Mar 10, 2025.

Applies to the following strengths: 8 mg

Usual Adult Dose for:

Insomnia

Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Dose Adjustments
Precautions
Dialysis
Other Comments

Usual Adult Dose for Insomnia

8 mg orally within 30 minutes of going to bed

Maximum Dose: 8 mg per day

Comments: This drug should not be taken with or immediately after a high-fat meal.

Use: Treatment of insomnia characterized by difficulty with sleep onset

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild Hepatic Impairment (Child-Pugh A): Data not available.
Moderate Hepatic Impairment (Child-Pugh B): Use with caution.
Severe Hepatic Impairment (Child-Pugh C): Not recommended.

Dose Adjustments

Concomitant Use of CYP450 1A2 Inhibiting Drugs: Contraindicated with fluvoxamine; Caution recommended if used with other CYP450 1A2 inhibitors.

Patients with Severe Sleep Apnea: Not recommended.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: No adjustment recommended.
Peritoneal dialysis: Data not available.

Other Comments

Administration Advice:

The drug tablet should be swallowed whole; tablets should not be broken.

Storage Requirements:

The container should be kept tightly closed to protect from moisture and humidity.

General:

This drug does not appear to produce physical dependence; treatment discontinuation after chronic administration did not produce withdrawal signs in humans or in animals.
If overdosage occurs, general symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate and IV fluids as needed.

Patient Advice:

Do not drink alcohol while taking this drug.
Do not take other medications that can make you sleepy while taking this drug.
Do not take this drug with food or right after a meal.
Do not take this drug unless you are able to get a full night's sleep before you must be active again.
After taking this drug, avoid driving and other activities that require concentration such as operating machinery; limit your activities to those necessary to prepare for bed.
Consult your healthcare provider if your insomnia worsens or is not better within 7 to 10 days.