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Propantheline Dosage

Medically reviewed by Last updated on Jan 26, 2023.

Applies to the following strengths: 15 mg; 7.5 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Peptic Ulcer

Initial dose: 15 mg orally 30 minutes before each meal AND 30 mg orally at bedtime


  • The initial daily dose is 75 mg.
  • Dose adjustments should be determined by the patient's age and tolerance.
  • This drug should be used with caution in older patients.

Use: Adjunctive treatment of peptic ulcers

Renal Dose Adjustments

Use with caution.

Liver Dose Adjustments

Use with caution.



  • Hypersensitivity to the active component or to any of the ingredients
  • Intestinal atony of older patients and/or those who are debilitated
  • Myasthenia gravis
  • Obstructive gastrointestinal tract disease (e.g., achalasia, paralytic stenosis, pyloroduodenal stenosis)
  • Obstructive uropathy (e.g., prostatic hypertrophy-related bladder neck obstruction)
  • Patients with glaucoma
  • Severe ulcerative colitis/toxic megacolon complicating ulcerative colitis
  • Unstable cardiovascular adjustment in acute hemorrhage

Safety and efficacy have not been established in children.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

  • This drug should be taken at least 30 to 60 minutes prior to meals.
  • If needed, antacid and/or absorbent antidiarrheal agents should be taken at least 2 to 3 hours from doses of this drug.

Storage requirements:
  • Protect from light and moisture; store at/below 25C.

  • Risks and benefits of treatment should be considered before treatment.

Patient advice:
  • Inform patients that this drug may cause drowsiness or blurred vision, and they should avoid driving or operating machinery if these side effects occur.
  • Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.