Propantheline Dosage

Medically reviewed by Drugs.com. Last updated on Jan 27, 2025.

Usual Adult Dose for Peptic Ulcer

Initial dose: 15 mg orally 30 minutes before each meal AND 30 mg orally at bedtime

Comments:

• The initial daily dose is 75 mg.
• Dose adjustments should be determined by the patient's age and tolerance.
• This drug should be used with caution in older patients.

Use: Adjunctive treatment of peptic ulcers

Renal Dose Adjustments

Use with caution.

Liver Dose Adjustments

Use with caution.

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to the active component or to any of the ingredients
• Intestinal atony of older patients and/or those who are debilitated
• Myasthenia gravis
• Obstructive gastrointestinal tract disease (e.g., achalasia, paralytic stenosis, pyloroduodenal stenosis)
• Obstructive uropathy (e.g., prostatic hypertrophy-related bladder neck obstruction)
• Patients with glaucoma
• Severe ulcerative colitis/toxic megacolon complicating ulcerative colitis
• Unstable cardiovascular adjustment in acute hemorrhage

Safety and efficacy have not been established in children.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug should be taken at least 30 to 60 minutes prior to meals.
• If needed, antacid and/or absorbent antidiarrheal agents should be taken at least 2 to 3 hours from doses of this drug.

Storage requirements:

• Protect from light and moisture; store at/below 25C.

General:

• Risks and benefits of treatment should be considered before treatment.

Patient advice:

• Inform patients that this drug may cause drowsiness or blurred vision, and they should avoid driving or operating machinery if these side effects occur.
• Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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