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Precedex Concentrate Dosage

Generic name: DEXMEDETOMIDINE HYDROCHLORIDE 100ug in 1mL
Dosage form: injection, solution, concentrate
Drug class: Miscellaneous anxiolytics, sedatives and hypnotics

Medically reviewed by Drugs.com. Last updated on Oct 22, 2024.

2.1 Dosing Guidelines

  • Precedex dosing should be individualized and titrated to desired clinical response.
  • Precedex is not indicated for infusions lasting longer than 24 hours.
  • Precedex should be administered using a controlled infusion device.

2.2 Dosage Information

Table 1: Dosage Information

INDICATION

DOSAGE AND ADMINISTRATION

Initiation of Intensive Care Unit Sedation

For adult patients: a loading infusion of one mcg/kg over 10 minutes.

For adult patients being converted from alternate sedative therapy:a loading dose may not be required.

For patients over 65 years of age: a dose reduction should be considered.

For adult patients with impaired hepatic-function: a dose reduction should be considered.

Maintenance of Intensive Care Unit Sedation

For adult patients: a maintenance infusion of 0.2 to 0.7 mcg/kg/hour. The rate of the maintenance infusion should be adjusted to achieve the desired level of sedation.

For patients over 65 years of age: a dose reduction should be considered.

For adult patients with impaired hepatic function: a dose reduction should be considered

Initiation of Procedural Sedation

For adult patients: a loading infusion of one mcg/kg over 10 minutes. For less invasive procedures such as ophthalmic surgery, a loading infusion of 0.5 mcg/kg given over 10 minutes may be suitable.

For awake fiberoptic intubation in adult patients: a loading infusion of one mcg/kg over 10 minutes.

For patients over 65 years of age: a loading infusion of 0.5 mcg/kg over 10 minutes.

For adult patients with impaired hepatic function: a dose reduction should be considered.

Maintenance of Procedural Sedation

For adult patients: the maintenance infusion is generally initiated at 0.6 mcg/kg/hour and titrated to achieve desired clinical effect with doses ranging from 0.2 to 1 mcg/kg/hour. The rate of the maintenance infusion should be adjusted to achieve the targeted level of sedation.

For awake fiberoptic intubation in adult patients: a maintenance infusion of 0.7 mcg/kg/hour is recommended until the endotracheal tube is secured.

For patients over 65 years of age: a dose reduction should be considered.

For adult patients with impaired hepatic function: a dose reduction should be considered.

2.3 Dosage Adjustment

Due to possible pharmacodynamic interactions, a reduction in dosage of Precedex or other concomitant anesthetics, sedatives, hypnotics or opioids may be required when co-administered.

Dosage reductions may need to be considered for adult patients with hepatic impairment, and geriatric patients.

2.4 Preparation of Solution

Strict aseptic technique must always be maintained during handling of Precedex.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Precedex Injection, 200 mcg/2 mL (100 mcg/mL)

Precedex must be diluted with 0.9% sodium chloride injection to achieve required concentration (4 mcg/mL) prior to administration. Preparation of solutions is the same, whether for the loading dose or maintenance infusion.

To prepare the infusion, withdraw 2 mL of Precedex Injection, and add to 48 mL of 0.9% sodium chloride injection to a total of 50 mL. Shake gently to mix well.

Precedex in 0.9% Sodium Chloride Injection, 80 mcg/20 mL (4 mcg/mL), 200 mcg/50 mL (4 mcg/mL) and 400 mcg/100 mL (4 mcg/mL)

Precedex in 0.9% Sodium Chloride Injection is supplied in glass containers containing a premixed, ready to use dexmedetomidine hydrochloride solution in 0.9% sodium chloride in water. No further dilution of these preparations are necessary.

2.5 Administration with Other Fluids

Precedex infusion should not be co-administered through the same intravenous catheter with blood or plasma because physical compatibility has not been established.

Precedex has been shown to be incompatible when administered with the following drugs: amphotericin B, diazepam.

Precedex has been shown to be compatible when administered with the following intravenous fluids:

•0.9% sodium chloride in water•5% dextrose in water•20% mannitol•Lactated Ringer's solution•100 mg/mL magnesium sulfate solution•0.3% potassium chloride solution

2.6 Compatibility with Natural Rubber

Compatibility studies have demonstrated the potential for absorption of Precedex to some types of natural rubber. Although Precedex is dosed to effect, it is advisable to use administration components made with synthetic or coated natural rubber gaskets.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.