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Precedex Side Effects

Generic Name: dexmedetomidine

Note: This document contains side effect information about dexmedetomidine. Some of the dosage forms listed on this page may not apply to the brand name Precedex.

In Summary

Common side effects of Precedex include: bradycardia, hypotension, agitation, hypertension, nausea, and tachycardia. Other side effects include: vomiting, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dexmedetomidine: parenteral injection concentrate

Side effects include:

Hypotension, hypertension, nausea, bradycardia, fever, vomiting, hypoxia, tachycardia, anemia.

For Healthcare Professionals

Applies to dexmedetomidine: intravenous solution

Cardiovascular

Very common (10% or more): Hypotension (56%), bradycardia (42%), systolic hypertension (28%), hypotension requiring intervention (28%), tachycardia (25%), hypertension requiring intervention (19%), hypertension (16%), diastolic hypertension (12%), tachycardia requiring intervention (10%)

Common (1% to 10%): Atrial fibrillation, sinus tachycardia, myocardial ischemia or infarction, bradycardia requiring intervention

Uncommon (0.1% to 1%): Ventricular tachycardia, atrioventricular block first degree, decreased cardiac output

Frequency not reported: Sinus arrest

Postmarketing reports: Arrhythmia, cardiac arrest, cardiac disorder, extrasystoles, supraventricular tachycardia, ventricular arrhythmia, electrocardiogram T wave inversion, prolonged QT, blood pressure fluctuation, heart block[Ref]

Respiratory

Very common (10% or more): Respiratory depression (37%)

Common (1% to 10%): Atelectasis, hypoxia, pulmonary edema, pleural effusion, respiratory failure, acute respiratory distress syndrome, bradypnea, pneumonia, pharyngolaryngeal pain

Uncommon (0.1% to 1%): Wheezing, dyspnea, apnea

Frequency not reported: Decreased respiratory rate

Postmarketing reports: Bronchospasm, hypercapnia, hypoventilation, pulmonary congestion, respiratory acidosis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (11%)

Common (1% to 10%): Dry mouth, vomiting, constipation, abdominal distension, abdominal pain, diarrhea[Ref]

Dermatologic

Common (1% to 10%): Decubitus ulcer

Uncommon (0.1% to 1%): Rash

Postmarketing reports: Hyperhidrosis[Ref]

Hematologic

Common (1% to 10%): Anemia

Uncommon (0.1% to 1%): Thrombocytopenia[Ref]

Metabolic

Common (1% to 10%): Hypovolemia, hyperglycemia, hypoglycemia, hypocalcemia, acidosis, hypokalemia, hypomagnesemia, hypernatremia, hypophosphatemia

Uncommon (0.1% to 1%): Metabolic acidosis, hypoalbuminemia, electrolyte imbalance

Postmarketing reports: Hyperkalemia, acidosis[Ref]

Nervous system

Common (1% to 10%): Headache

Postmarketing reports: Convulsion, dizziness, neuralgia, neuritis, speech disorder[Ref]

Other

Common (1% to 10%): Pyrexia, hyperthermia, chills, post-procedural hemorrhage, withdrawal event/syndrome, rigors, hyperpyrexia, pain, thirst, generalized edema, peripheral edema, sepsis, septic shock

Uncommon (0.1% to 1%): Ineffective drug

Frequency not reported: Tolerance, tachyphylaxis

Postmarketing reports: Light anesthesia[Ref]

Psychiatric

Common (1% to 10%): Agitation, anxiety

Uncommon (0.1% to 1%): Hallucination

Postmarketing reports: Confusional state, delirium, illusion[Ref]

Renal

Common (1% to 10%): Acute renal failure, decreased urine output, oliguria

Postmarketing reports: Increased blood urea, polyuria[Ref]

Hepatic

Postmarketing reports: Abnormal hepatic function, hyperbilirubinemia, increased ALT, increased AST, increased blood alkaline phosphatase, increased gamma-glutamyl transferase[Ref]

Ocular

Frequency not reported: Reduced lacrimation

Postmarketing reports: Photopsia, abnormal vision, visual impairment[Ref]

References

1. "Product Information. Precedex (dexmedetomidine)" Abbott Pharmaceutical, Abbott Park, IL.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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