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Precedex Side Effects

Generic Name: dexmedetomidine

Note: This page contains side effects data for the generic drug dexmedetomidine. It is possible that some of the dosage forms included below may not apply to the brand name Precedex.

In Summary

Common side effects of Precedex include: bradycardia, hypotension, agitation, tachycardia, hypertension, and nausea. Other side effects include: vomiting, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dexmedetomidine: parenteral injection concentrate

Side effects include:

Hypotension, hypertension, nausea, bradycardia, fever, vomiting, hypoxia, tachycardia, anemia.

For Healthcare Professionals

Applies to dexmedetomidine: intravenous solution


Very common (10% or more): Hypotension (56%), bradycardia (42%), systolic hypertension (28%), hypotension requiring intervention (28%), tachycardia (25%), hypertension requiring intervention (19%), hypertension (16%), diastolic hypertension (12%), tachycardia requiring intervention (10%)
Common (1% to 10%): Atrial fibrillation, sinus tachycardia, myocardial ischemia or infarction, bradycardia requiring intervention
Uncommon (0.1% to 1%): Ventricular tachycardia, atrioventricular block first degree, decreased cardiac output
Frequency not reported: Sinus arrest
Postmarketing reports: Arrhythmia, cardiac arrest, cardiac disorder, extrasystoles, supraventricular tachycardia, ventricular arrhythmia, electrocardiogram T wave inversion, prolonged QT, blood pressure fluctuation, heart block[Ref]


Very common (10% or more): Respiratory depression (37%)
Common (1% to 10%): Atelectasis, hypoxia, pulmonary edema, pleural effusion, respiratory failure, acute respiratory distress syndrome, bradypnea, pneumonia, pharyngolaryngeal pain
Uncommon (0.1% to 1%): Wheezing, dyspnea, apnea
Frequency not reported: Decreased respiratory rate
Postmarketing reports: Bronchospasm, hypercapnia, hypoventilation, pulmonary congestion, respiratory acidosis[Ref]


Very common (10% or more): Nausea (11%)
Common (1% to 10%): Dry mouth, vomiting, constipation, abdominal distension, abdominal pain, diarrhea[Ref]


Common (1% to 10%): Decubitus ulcer
Uncommon (0.1% to 1%): Rash
Postmarketing reports: Hyperhidrosis[Ref]


Common (1% to 10%): Anemia
Uncommon (0.1% to 1%): Thrombocytopenia[Ref]


Common (1% to 10%): Hypovolemia, hyperglycemia, hypoglycemia, hypocalcemia, acidosis, hypokalemia, hypomagnesemia, hypernatremia, hypophosphatemia
Uncommon (0.1% to 1%): Metabolic acidosis, hypoalbuminemia, electrolyte imbalance
Postmarketing reports: Hyperkalemia, acidosis[Ref]

Nervous system

Common (1% to 10%): Headache
Postmarketing reports: Convulsion, dizziness, neuralgia, neuritis, speech disorder[Ref]


Common (1% to 10%): Pyrexia, hyperthermia, chills, post-procedural hemorrhage, withdrawal event/syndrome, rigors, hyperpyrexia, pain, thirst, generalized edema, peripheral edema, sepsis, septic shock
Uncommon (0.1% to 1%): Ineffective drug
Frequency not reported: Tolerance, tachyphylaxis
Postmarketing reports: Light anesthesia[Ref]


Common (1% to 10%): Agitation, anxiety
Uncommon (0.1% to 1%): Hallucination
Postmarketing reports: Confusional state, delirium, illusion[Ref]


Common (1% to 10%): Acute renal failure, decreased urine output, oliguria
Postmarketing reports: Increased blood urea, polyuria[Ref]


Postmarketing reports: Abnormal hepatic function, hyperbilirubinemia, increased ALT, increased AST, increased blood alkaline phosphatase, increased gamma-glutamyl transferase[Ref]


Frequency not reported: Reduced lacrimation
Postmarketing reports: Photopsia, abnormal vision, visual impairment[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Precedex (dexmedetomidine)" Abbott Pharmaceutical, Abbott Park, IL.

It is possible that some side effects of Precedex may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.