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Polythiazide / Prazosin Dosage

Applies to the following strengths: 0.5 mg-1 mg; 0.5 mg-2 mg; 0.5 mg-5 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: 1 capsule of (polythiazide-prazosin 0.5 mg/1 mg) 2-3 times a day. Determine dosage by individual titration.
Maintenance dose: May increase up to a maximum of 2 capsules of (polythiazide-prazosin 0.5 mg/5 mg) twice a day.

Dose Adjustments

The dose may be titrated as necessary once a week.


Thiazide diuretics should be used with caution in patients with severe renal disease and/or hepatic impairment.


Prazosin is not dialyzable because it is protein bound.

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.