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Odomzo Dosage

Generic name: SONIDEGIB PHOSPHATE 200mg
Dosage form: capsule
Drug class: Hedgehog pathway inhibitors

Medically reviewed by Last updated on Aug 29, 2023.

Important Safety Information

Verify the pregnancy status of females of reproductive potential prior to initiating ODOMZO [see Use in Specific Populations (8.1, 8.3)].

Recommended Dosage

The recommended dosage of ODOMZO is 200 mg taken orally once daily on an empty stomach, at least 1 hour before or 2 hours after a meal, administered until disease progression or unacceptable toxicity [see Clinical Pharmacology (12.3)].

Obtain serum creatine kinase (CK) levels and renal function tests prior to initiating ODOMZO in all patients [see Dosage and Administration (2.2) and Warnings and Precautions (5.2)].

If a dose of ODOMZO is missed, resume dosing with the next scheduled dose.

Dosage Modifications for Adverse Reactions

Interrupt ODOMZO for

  • Severe or intolerable musculoskeletal adverse reactions.
  • First occurrence of serum CK elevation between 2.5 and 10 times upper limit of normal (ULN).
  • Recurrent serum CK elevation between 2.5 and 5 times ULN.

Resume ODOMZO at 200 mg daily upon resolution of clinical signs and symptoms.

Permanently discontinue ODOMZO for

  • Serum CK elevation greater than 2.5 times ULN with worsening renal function.
  • Serum CK elevation greater than 10 times ULN.
  • Recurrent serum CK elevation greater than 5 times ULN.
  • Recurrent severe or intolerable musculoskeletal adverse reactions.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.