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Odomzo Side Effects

Generic Name: sonidegib

Note: This page contains side effects data for the generic drug sonidegib. It is possible that some of the dosage forms included below may not apply to the brand name Odomzo.

In Summary

Common side effects of Odomzo include: muscle spasm, musculoskeletal pain, and myalgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to sonidegib: oral capsule

As well as its needed effects, sonidegib (the active ingredient contained in Odomzo) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking sonidegib, check with your doctor immediately:

More common:
  • Difficulty with moving
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • muscle spasms
  • swollen joints
Rare
  • Dark-colored urine
  • fever
  • muscle stiffness
  • unusual tiredness or weakness

Minor Side Effects

Some sonidegib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Abdominal or stomach pain
  • change in taste
  • decreased appetite
  • decreased weight
  • diarrhea
  • hair loss or thinning of the hair
  • headache
  • itching skin
  • loss of taste
  • nausea
  • vomiting

For Healthcare Professionals

Applies to sonidegib: oral capsule

General

Adverse reactions reported in at least 2 patients that led to discontinuation of this drug were muscle spasms, dysgeusia, asthenia, increased lipase, nausea, fatigue, decreased appetite, alopecia, and decreased weight. Serious adverse reactions occurred in 18% of patients.[Ref]

Musculoskeletal

75% of patients with increased serum creatinine had levels that remained within normal range.[Ref]

Very common (10% or more): Increased serum creatinine (92%), increased serum creatinine kinase (61%), muscle spasms (54%), musculoskeletal pain (32%), myalgia (19%)
Uncommon (0.1% to 1%): Rhabdomyolysis[Ref]

Dermatologic

Very common (10% or more): Alopecia (53%), pruritus (10%)[Ref]

Metabolic

Very common (10% or more): Hyperglycemia (51%), decreased weight (30%), decreased appetite (23%)[Ref]

Nervous system

Very common (10% or more): Dysgeusia (46%), headache (15%)[Ref]

Gastrointestinal

Very common (10% or more): Increased lipase (43%), nausea (39%), diarrhea (32%), abdominal pain (18%), increased amylase (16%), vomiting (11%)[Ref]

Other

Very common (10% or more): Fatigue (41%), pain (14%)[Ref]

Hematologic

Very common (10% or more): Anemia (32%), lymphopenia (28%)[Ref]

Hepatic

Very common (10% or more): Increased ALT (19%), increased AST (19%)[Ref]

Endocrine

Frequency not reported: Amenorrhea[Ref]

References

1. "Product Information. Odomzo (sonidegib)." Novartis Pharmaceuticals, East Hanover, NJ.

It is possible that some side effects of Odomzo may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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