Odomzo Side Effects
Generic Name: sonidegib
Note: This page contains side effects data for the generic drug sonidegib. It is possible that some of the dosage forms included below may not apply to the brand name Odomzo.
Common side effects of Odomzo include: muscle spasm, musculoskeletal pain, and myalgia. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to sonidegib: oral capsule
As well as its needed effects, sonidegib (the active ingredient contained in Odomzo) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking sonidegib, check with your doctor immediately:More common:
- Difficulty with moving
- joint pain
- muscle aching or cramping
- muscle pains or stiffness
- muscle spasms
- swollen joints
- Dark-colored urine
- muscle stiffness
- unusual tiredness or weakness
Minor Side Effects
Some sonidegib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common:
- Abdominal or stomach pain
- change in taste
- decreased appetite
- decreased weight
- hair loss or thinning of the hair
- itching skin
- loss of taste
For Healthcare Professionals
Applies to sonidegib: oral capsule
Adverse reactions reported in at least 2 patients that led to discontinuation of this drug were muscle spasms, dysgeusia, asthenia, increased lipase, nausea, fatigue, decreased appetite, alopecia, and decreased weight. Serious adverse reactions occurred in 18% of patients.[Ref]
75% of patients with increased serum creatinine had levels that remained within normal range.[Ref]
Very common (10% or more): Increased serum creatinine (92%), increased serum creatinine kinase (61%), muscle spasms (54%), musculoskeletal pain (32%), myalgia (19%)
Uncommon (0.1% to 1%): Rhabdomyolysis[Ref]
Very common (10% or more): Alopecia (53%), pruritus (10%)[Ref]
Very common (10% or more): Hyperglycemia (51%), decreased weight (30%), decreased appetite (23%)[Ref]
Very common (10% or more): Dysgeusia (46%), headache (15%)[Ref]
Very common (10% or more): Increased lipase (43%), nausea (39%), diarrhea (32%), abdominal pain (18%), increased amylase (16%), vomiting (11%)[Ref]
Very common (10% or more): Fatigue (41%), pain (14%)[Ref]
Very common (10% or more): Anemia (32%), lymphopenia (28%)[Ref]
Very common (10% or more): Increased ALT (19%), increased AST (19%)[Ref]
Frequency not reported: Amenorrhea[Ref]
1. "Product Information. Odomzo (sonidegib)." Novartis Pharmaceuticals, East Hanover, NJ.
It is possible that some side effects of Odomzo may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
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