Odomzo Side Effects
Generic name: sonidegib
Medically reviewed by Drugs.com. Last updated on Mar 1, 2021.
Note: This document contains side effect information about sonidegib. Some of the dosage forms listed on this page may not apply to the brand name Odomzo.
Common side effects of Odomzo include: muscle spasm, musculoskeletal pain, and myalgia. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to sonidegib: oral capsule
Oral route (Capsule)
Use of sonidegib during pregnancy can cause embryofetal death or severe birth defects. Verify pregnancy status prior to initiating treatment and advise females of reproductive potential to use adequate contraception during treatment and for at least 20 months after discontinuation. Male patients with a female partner of reproductive potential must be advised to use adequate contraception during treatment for at least 8 months after discontinuation.
Side effects requiring immediate medical attention
Along with its needed effects, sonidegib (the active ingredient contained in Odomzo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sonidegib:
- Difficulty with moving
- joint pain
- muscle aching or cramping
- muscle pains or stiffness
- muscle spasms
- swollen joints
- Dark-colored urine
- muscle stiffness
- unusual tiredness or weakness
Side effects not requiring immediate medical attention
Some side effects of sonidegib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Abdominal or stomach pain
- change in taste
- decreased appetite
- decreased weight
- hair loss or thinning of the hair
- itching skin
- loss of taste
For Healthcare Professionals
Applies to sonidegib: oral capsule
Very common (10% or more): Increased serum creatinine (92%), increased serum creatinine kinase (61%), muscle spasms (54%), musculoskeletal pain (32%), myalgia (19%)
Uncommon (0.1% to 1%): Rhabdomyolysis[Ref]
75% of patients with increased serum creatinine had levels that remained within normal range.[Ref]
Common (1% to 10%): Rash, abnormal hair growth[Ref]
Very common (10% or more): Hyperglycemia (51%), dysgeusia (46%), decreased weight (30%), decreased appetite (23%)
Very common (10% or more): Dysgeusia (46%), headache (15%)[Ref]
Very common (10% or more): Increased lipase (43%), nausea (39%), diarrhea (32%), abdominal pain (18%), increased amylase (16%), vomiting (11%)
Very common (10% or more): Fatigue (41%), pain (14%)[Ref]
Very common (10% or more): Anemia (32%), lymphopenia (28%)[Ref]
Very common (10% or more): Increased ALT (19%), increased AST (19%)[Ref]
Frequently asked questions
More about Odomzo (sonidegib)
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 1 Review
- Drug class: hedgehog pathway inhibitors
- FDA Approval History
Related treatment guides
1. "Product Information. Odomzo (sonidegib)." Novartis Pharmaceuticals, East Hanover, NJ.
2. Cerner Multum, Inc. "Australian Product Information." O 0
Some side effects may not be reported. You may report them to the FDA.