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How does Odomzo work?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on March 13, 2023.

Official answer


Odomzo is classified as a Hedgehog pathway inhibitor, and helps to block this molecular pathway which is active in locally advanced basal cell (skin) cancers. Odomzo binds to and inhibits Smoothened, a protein involved in the Hedgehog pathway. By suppressing the Hedgehog pathway, Odomzo may stop or slow the growth of cancer lesions.

Odomzo (generic name: sonidegib) is a cancer medicine that is used to treat locally advanced basal cell carcinoma (a type of skin cancer) in adults.

  • Odomzo is used when surgery or radiation treatment for the skin cancer cannot be used or have not been successful.
  • It is given as an oral capsule taken once a day on an empty stomach, at least 1 hour before or 2 hours after a meal.
  • Your doctor may have you continue this medicine until your disease progresses or you have unacceptable side effects. Always follow your doctor's dose instructions.

This is not all the information you need to know about Odomzo for safe and effective use and does not take the place of talking to your doctor about your treatment. Review the full Odomzo product information here, and discuss this information and any questions you have with your doctor or other health care provider.


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