Lipofen Dosage
Generic name: FENOFIBRATE 50mg
Dosage form: capsule
Drug class: Fibric acid derivatives
Medically reviewed by Drugs.com. Last updated on Jun 18, 2025.
Prior to Initiation of LIPOFEN
- Assess lipid levels before initiating therapy. Identify other causes (e.g., diabetes mellitus, hypothyroidism, or medications) of high TG levels and manage as appropriate.
- Patients should be placed on an appropriate lipid-lowering diet before receiving LIPOFEN, and should continue this diet during treatment with LIPOFEN.
- In patients with diabetes and fasting chylomicronemia, improve glycemic control prior to considering starting LIPOFEN.
Recommended Dosage and Administration
- Severe hypertriglyceridemia:
- The recommended dosage of LIPOFEN is 50 mg or 150 mg orally once daily.
- Dosage should be individualized according to patient response, and should be adjusted if necessary following repeat lipid determinations at 4 to 8 week intervals.
- Primary hyperlipidemia:
- The recommended dosage of LIPOFEN is 150 mg orally once daily.
- Administer LIPOFEN as a single dose at any time of day, with food.
- Advise patients to swallow LIPOFEN capsules whole. Do not crush, break, dissolve, or chew capsules.
- Assess TG when clinically appropriate, as early as 4 to 8 weeks after initiating LIPOFEN. Discontinue LIPOFEN in patients who do not have an adequate response after 2 months of treatment.
- If a dose is missed, advise patients not to take an extra dose. Resume treatment with the next dose.
- Advise patients to take LIPOFEN at least 1 hour before or 4 hours to 6 hours after a bile acid binding resin to avoid impeding its absorption.
Recommended Dosage in Patients with Renal Impairment
- Assess renal function prior to initiation of LIPOFEN and periodically thereafter.
- Treatment with LIPOFEN should be initiated at a dosage of 50 mg orally once daily in patients with mild to moderately impaired renal function (eGFR 30 to <60 mL/min/1.73m2), and increased only after evaluation of the effects on renal function and TG levels at this dosage.
- LIPOFEN is contraindicated in patients with severe renal impairment (eGFR <30 mL/min/1.73m2), including those with end-stage renal disease (ESRD) and those receiving dialysis.
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