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Insulin Glargine Dosage

Medically reviewed by Drugs.com. Last updated on Aug 11, 2023.

Applies to the following strengths: 100 units/mL; aglr 100 units/mL; 300 units/mL; yfgn 100 units/mL

Usual Adult Dose for Diabetes Type 1

Dose should be individualized: Must be used concomitantly with shorter acting (i.e., prandial/bolus) insulin

Insulin glargine 100 units/mL (U-100):


Insulin glargine 300 units/mL (U-300):

DOSE-CONVERSION Between U-100 and U-300:
DOSE-CONVERSIONS From Intermediate or Long-Acting Insulins to Insulin Glargine:

Maintenance doses: Once the switch is made, doses should be adjusted as described above for maintenance doses

Comments:

Use: To improve glycemic control in patients with type 1 diabetes mellitus.

Usual Adult Dose for Diabetes Type 2

Dose should be individualized based on clinical response

Insulin-naive:


Special considerations for insulin glargine U-300 insulin:

DOSE-CONVERSION Between U-100 and U-300:
DOSE-CONVERSIONS From Intermediate or Long-Acting Insulins to Insulin Glargine:

Maintenance doses: Once the switch is made, doses should be adjusted as described above for maintenance doses

Comments:

Use: To improve glycemic control in patients with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2

Initial dosing, dose increments, and maintenance dosage should be conservative to avoid hypoglycemic reactions.

Usual Geriatric Dose for Diabetes Type 1

Initial dosing, dose increments, and maintenance dosage should be conservative to avoid hypoglycemic reactions.

Usual Pediatric Dose for Diabetes Type 1

Age: 6 years or older:
Dose should be individualized: Must be used concomitantly with shorter acting (i.e., prandial/bolus) insulin

Insulin glargine 100 units/mL (U-100):


Insulin glargine 300 units/mL (U-300):

DOSE-CONVERSION Between U-100 and U-300:
DOSE-CONVERSIONS From Intermediate or Long-Acting Insulins to Insulin Glargine:

Maintenance doses: Once the switch is made, doses should be adjusted as described above for maintenance doses

Comments:

Use: To improve glycemic control in pediatric patients 6 years or older with type 1 diabetes mellitus.

Usual Pediatric Dose for Diabetes Type 2

Age: 6 years or older:

Insulin-naive:


Special considerations for insulin glargine U-300 insulin:

DOSE-CONVERSIONS From Intermediate or Long-Acting Insulins to Insulin Glargine:

Maintenance doses: Once the switch is made, doses should be adjusted as described above for maintenance doses

Comments:

Use: To improve glycemic control in patients with type 2 diabetes mellitus.

Renal Dose Adjustments

Use with caution; frequent glucose monitoring and insulin dose reduction may be required

Liver Dose Adjustments

Use with caution; frequent glucose monitoring and insulin dose reduction may be required

Dose Adjustments

Daily insulin requirements may be higher during illness, stress, pregnancy, in obese patients, trauma, during concurrent use with medications having hyperglycemic effects, or after surgery

Daily insulin requirements may be lower with exercise, weight loss, calorie restricted diets, or during concurrent use of medications having hypoglycemic effects

Supplemental doses may be prescribed during illness; patients with type 2 diabetes receiving oral medications may be switched to insulin therapy temporarily

Dosage adjustments may be required when the brand, type, or species of insulin is changed; oral antidiabetic treatment may need to be adjusted as well

Precautions

CONTRAINDICATIONS:



Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Insulin Glargine is available in 2 concentrations: 100 units/mL (U-100) and 300 units/mL (U-300)

Preparation and Instructions for Use:

Storage requirements: Do not freeze; discard if frozen

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.