Inamrinone Dosage

Usual Adult Dose for Congestive Heart Failure

Loading dose: 0.75 mg/kg IV undiluted over 2 to 3 minutes.
Maintenance infusion: 5 to 10 mcg/kg/min.

Usual Pediatric Dose for Congestive Heart Failure

(Not approved by FDA)

less than 1 month:
IV: 0.75 mg/kg IV bolus over 2 to 3 minutes followed by continuous IV infusion at 3 to 5 mcg/kg/minute; titrate infusion based on patient clinical response and adverse effects; IV bolus may need to be repeated in 30 minutes; maximum dose: 10 mg/kg/24 hours.
1 month and older:
0.75 mg/kg IV bolus over 2 to 3 minutes followed by maintenance infusion 5 to 10 mcg/kg/minute; IV bolus may need to be repeated in 30 minutes.

Renal Dose Adjustments

under 18 years:
CrCl less than 10 mL/minute: Administer 25% of dose
CrCl 10 to 29 mL/minute: Administer 50% of dose
CrCl 30 to 50 mL/minute: Administer 100% of dose

Adults:
CrCl less than 10 mL/minute: Administer 50% to 75% of dose
CrCl greater than 10 mL/minute: Administer 100% of dose

Liver Dose Adjustments

Data not available

Dose Adjustments

An additional 45 mg IV bolus can be administered, if necessary, after starting inamrinone therapy.
The maintenance infusion should be adjusted to the patient's response.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Intermittent hemodialysis or peritoneal dialysis: Administer 25% of dose

Other Comments

The maximum recommended daily dose is 10 mg/kg (including the loading doses). Doses as high as 18 mg/kg have been used in a limited number of patients for shortened durations of therapy.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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