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Hydralazine / Isosorbide Dinitrate Dosage

Medically reviewed by Last updated on Jun 22, 2022.

Applies to the following strengths: 37.5 mg-20 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Congestive Heart Failure

Initial dose: Hydralazine 37.5 mg-Isosorbide dinitrate 20 mg orally three times a day
Maximum dose: Hydralazine 75 mg-Isosorbide dinitrate 40 mg orally three times a day


  • May titrate up every 3 to 5 days, but some patients may experience side effects and take longer to reach their maximum tolerated dose.
  • May decrease as low as hydralazine 18.75 mg-isosorbide dinitrate 10 mg three times a day if intolerable side effects occur; should titrate up as soon as side effects subside.

Use: Treatment of heart failure as an adjunct to standard therapy in self-identified black patients to improve survival, prolong time to hospitalization for heart failure, and improve patient-reported functional status. Experience in patients with New York Heart Association (NYHA) class IV heart failure is limited.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution is recommended.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.