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Endocet Dosage

Dosage form: tablet

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Important Dosage and Administration Instructions

Initiate the dosing regimen for each patient individually, taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk factors for addiction, abuse, and misuse (see WARNINGS).

Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy and following dosage increases with ENDOCET and adjust the dosage accordingly (see WARNINGS).

Initial Dosage

Initiating Treatment with ENDOCET

Initiate treatment with ENDOCET tablets 2.5 mg/325 mg adult dosage, with one or 2 tablets every 6 hours as needed for pain. 

The total daily dose of acetaminophen should not exceed 4 grams.

Initiate treatment with ENDOCET tablets 5 mg/325 mg; ENDOCET tablets 7.5 mg/325 mg; ENDOCET tablets 10 mg/325 mg, adult dosage, with one tablet every 6 hours as needed for pain. The total daily dose of acetaminophen should not exceed 4 grams.

Strength  Maximal Daily Dose
 ENDOCET 2.5 mg/325 mg  12 Tablets
 ENDOCET 5 mg/325 mg  12 Tablets
 ENDOCET 7.5 mg/325 mg  8 Tablets
 ENDOCET 10 mg/325 mg  6 Tablets

Titration and Maintenance of Therapy

Individually titrate ENDOCET to a dose that provides adequate analgesia and minimizes adverse reactions. Continually reevaluate patients receiving ENDOCET to assess the maintenance of pain control and the relative incidence of adverse reactions, as well as monitoring for the development of addiction, abuse, or misuse (see WARNINGS). Frequent communication is important among the prescriber, other members of the healthcare team, the patient, and the caregiver/family during periods of changing analgesic requirements, including initial titration.

If the level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing the ENDOCET dosage. If unacceptable opioid-related adverse reactions are observed, consider reducing the dosage. Adjust the dosage to obtain an appropriate balance between management of pain and opioid-related adverse reactions.

Discontinuation of ENDOCET tablets

When a patient who has been taking ENDOCET regularly and may be physically dependent no longer requires therapy with ENDOCET, use a gradual downward titration of the dosage to prevent signs and symptoms of withdrawal. Do not stop ENDOCET abruptly (see WARNINGS, DRUG ABUSE AND DEPENDENCE).