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Diclofenac / Fluorouracil Topical Dosage

Applies to the following strengths: 1%-5%

Usual Adult Dose for Keratosis

Apply cream or solution twice a day in an amount sufficient to cover the lesions
Duration of therapy: 2 to 4 weeks

-This drug should be continued until the inflammatory response reaches the erosion stage, at which time use of the drug should be discontinued.
-Complete healing of lesions may not be evident for at least 1 month following cessation.
-Solar keratoses which do not respond should be biopsied to confirm the diagnosis.

Uses: Topical treatment of multiple actinic or solar keratosis

Usual Adult Dose for Basal Cell Carcinoma

Apply cream or solution twice a day in an amount sufficient to cover the lesions

-The diagnosis should be established prior to treatment, since this method has not been proven effective in other types of basal cell carcinomas.
-Only the 5% strength is recommended for this condition.
-Treatment should be continued for at least 3 to 6 weeks. Therapy may be required for as long as 12 weeks.
-The patient should be followed for a reasonable period of time to determine if a cure has been obtained.

Uses: Treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:
-This drug should be applied preferably with a nonmetal applicator or suitable glove. If it is applied with the fingers, the hands should be washed immediately afterward.
-This drug should not be applied on the eyelids or directly into the eyes, nose or mouth.
-When this drug is applied to a lesion, a response occurs with the following sequence: erythema, usually followed by vesiculation, desquamation, erosion and reepithelialization.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.