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Degarelix Dosage

Medically reviewed by Last updated on May 13, 2020.

Applies to the following strengths: 80 mg; 120 mg

Usual Adult Dose for Prostate Cancer

-Initial Dose: 240 mg administered as 2 subcutaneous injections of 120 mg each at a concentration of 40 mg/mL.

-Maintenance Dose: 80 mg administered as 1 subcutaneous injection at a concentration of 20 mg/mL every 28 days.

Comments: Administer the first maintenance dose 28 days after the initial dose.

Use: Treatment of advanced prostate cancer

Renal Dose Adjustments

-Mild Renal Impairment (CrCl 50 to 80 mL/min): No adjustment recommended.
-Moderate to Severe Renal Impairment (CrCl less than 50 mL/min): Use with caution.

Liver Dose Adjustments

-Mild to Moderate Hepatic Impairment (Child-Pugh A and B): No adjustment recommended.
-Severe Hepatic Impairment (Child-Pugh C): Data not available; use with caution.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available.

Other Comments

Administration Advice:
-Administer this drug in the abdominal region only.
-Vary the injection site periodically to minimize patient discomfort, and administer in abdomen areas not exposed to pressure (e.g., not close to waistband or belt, not close to the ribs).
-Perform a slow, deep subcutaneous injection over 30 seconds.
-This drug is for subcutaneous injection only; do not administer intravenously or intramuscularly.
-Use this drug only as a first-line androgen deprivation therapy; there is no data available on use of this drug in patients who have failed treatment with GnRH agonists (e.g., leuprorelin, goserelin).
-Confirm serum testosterone levels are remaining sufficiently suppressed if a patient's clinical response appears to be sub-optimal.

Reconstitution/Preparation Techniques:
-Consult the manufacturer product information.

-This drug has shown to be effective in achieving and maintaining testosterone suppression below the medical castration level of 0.5 ng/mL.
-There is no clinical experience with the effects of an acute overdose.

-PSA serum concentrations; testosterone serum concentrations of testosterone (if PSA increases)
-ECG and electrolytes

Patient Advice:
-Do not rub, massage, or scratch the injection site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.