Medically reviewed by Drugs.com. Last updated on May 3, 2022.
Applies to the following strengths: 80 mg; 120 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Prostate Cancer
- Initial Dose: 240 mg administered as 2 subcutaneous injections of 120 mg each at a concentration of 40 mg/mL.
- Maintenance Dose: 80 mg administered as 1 subcutaneous injection at a concentration of 20 mg/mL every 28 days.
Comments: Administer the first maintenance dose 28 days after the initial dose.
Use: Treatment of advanced prostate cancer
Renal Dose Adjustments
- Mild Renal Impairment (CrCl 50 to 80 mL/min): No adjustment recommended.
- Moderate to Severe Renal Impairment (CrCl less than 50 mL/min): Use with caution.
Liver Dose Adjustments
- Mild to Moderate Hepatic Impairment (Child-Pugh A and B): No adjustment recommended.
- Severe Hepatic Impairment (Child-Pugh C): Data not available; use with caution.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available.
- Administer this drug in the abdominal region only.
- Vary the injection site periodically to minimize patient discomfort, and administer in abdomen areas not exposed to pressure (e.g., not close to waistband or belt, not close to the ribs).
- Perform a slow, deep subcutaneous injection over 30 seconds.
- This drug is for subcutaneous injection only; do not administer intravenously or intramuscularly.
- Use this drug only as a first-line androgen deprivation therapy; there is no data available on use of this drug in patients who have failed treatment with GnRH agonists (e.g., leuprorelin, goserelin).
- Confirm serum testosterone levels are remaining sufficiently suppressed if a patient's clinical response appears to be sub-optimal.
- Consult the manufacturer product information.
- This drug has shown to be effective in achieving and maintaining testosterone suppression below the medical castration level of 0.5 ng/mL.
- There is no clinical experience with the effects of an acute overdose.
- PSA serum concentrations; testosterone serum concentrations of testosterone (if PSA increases)
- ECG and electrolytes
- Do not rub, massage, or scratch the injection site.
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