Applies to the following strengths: 500 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hyperlipidemia
500 mg orally 4 times a day.
Renal Dose Adjustments
CrCl < 10 mL/min: Not recommended.
CrCl 10 to 50 mL/min: 500 mg orally every 12 to 18 hours.
CrCl > 50 mL/min: 500 mg orally every 6 to 12 hours.
Liver Dose Adjustments
Clofibrate is considered contraindicated in patients with significant hepatic dysfunction.
It is contraindicated in patients with clinically significant hepatic dysfunction.
Clofibrate has been shown to have an average elimination half-life of 133 hours in patients undergoing hemodialysis.
Some patients may respond to lower doses.