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Clofibrate Pregnancy and Breastfeeding Warnings

Clofibrate is also known as: Atromid-S

Clofibrate Pregnancy Warnings

Animal data suggest that clofibrate crosses the placenta and is measurable, but similar data in humans is not available. No reports of congenital malformations are available. The glucuronide metabolic system is responsible for metabolism of clofibrate, and because this system is immature in the newborn, the risk for accumulation is present. Therefore, the use of clofibrate at or near term is not recommended. The manufacturer considers the use of clofibrate contraindicated at any time during pregnancy. Reliable birth control measures should be used in women of childbearing potential. Withdrawal of clofibrate several months before conception should be considered.

Clofibrate has been assigned to pregnancy category C by the FDA. Animal reproduction studies have not been conducted, although animal data does suggest placental transfer. There are no controlled data in human pregnancy. Clofibrate is considered contraindicated during pregnancy.

See references

Clofibrate Breastfeeding Warnings

The active metabolite of clofibrate (clofibric acid) is excreted into human milk. The manufacturer considers clofibrate contraindicated during breast-feeding.

See references

References for pregnancy information

  1. "Product Information. Atromid-S (clofibrate)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  2. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):

References for breastfeeding information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. Cayen MN "Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man." Pharmacol Ther 29 (1985): 157-204
  3. "Product Information. Atromid-S (clofibrate)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

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