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Cisapride Dosage

Applies to the following strengths: 10 mg; 20 mg; 1 mg/mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Gastroesophageal Reflux Disease

10 mg orally 4 times a day 15 minutes before meals and at bedtime.
May be increased to 20 mg per dose if necessary.

Usual Adult Dose for Gastroparesis

10 mg orally 4 times a day 15 minutes before meals and at bedtime.
May be increased to 20 mg per dose if necessary.

Usual Adult Dose for Dyspepsia

5 mg orally 3 times a day 15 minutes before meals.
May be increased to 10 mg per dose if necessary.

Usual Pediatric Dose for Gastroesophageal Reflux Disease

>1 year: 0.2 to 0.3 mg/kg/dose orally 3 to 4 times a day.
Maximum: 10 mg per dose.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Reduce daily dosage by 50%.

Precautions

Cisapride is primarily metabolized by the hepatic cytochrome P-450 3A4 isoenzyme system. Any drug given concomitantly that inhibits the P-450 3A4 enzyme system, can lead to elevated cisapride blood levels.

Cisapride is contraindicated in patients with a gastrointestinal hemorrhage, mechanical bowel obstruction, bowel perforation, eating disorders, persistent vomiting, or other disorders in which an increase in gastrointestinal motility could be harmful.

Before beginning therapy all patients should have a 12-lead EKG (to measure QT interval). Cisapride should not be used in patients with a prolonged QT interval at baseline, those with a history of torsades de pointes, or those with long QT syndrome. Similarly, cisapride should be avoided in patients with sinus node dysfunction, and in those with second or third degree atrioventricular block.

Cisapride is contraindicated in patients taking any other drugs known to prolong the QT interval and increase the risk of arrhythmias (such as certain antipsychotics, antiarrhythmic, antidepressants, astemizole, bepridil, sparfloxacin, terodiline, etc.).

The rate of absorption of concomitantly administered drugs may be affected by the acceleration of gastric emptying caused by cisapride. Drugs with a narrow therapeutic index, or other drugs that require titration should be monitored closely.

Other Comments

Available via limited-access protocol only directly through Janssen Pharmaceutical. Contact number: 1-800-Janssen.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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