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Cefonicid Dosage

Applies to the following strengths: 1 g

Usual Adult Dose for Pneumonia

Mild to moderate infections: 1 g IV or intramuscularly every 24 hours.

Severe or life-threatening infections: 2 g IV every 24 hours.

Usual Adult Dose for Urinary Tract Infection

Uncomplicated: 0.5 g IV or intramuscularly once every 24 hours.

Usual Adult Dose for Surgical Prophylaxis

Preoperative: 1 g IV or intramuscularly 60 minutes prior to procedure.
Intraoperative: not necessary.
Postoperative: 1 g IV or intramuscularly may be administered for 2 additional days in patients undergoing prosthetic arthroplasty or open heart surgery.

Usual Adult Dose for Cesarean Section

1 g IV or intramuscularly after the umbilical cord has been clamped.

Usual Adult Dose for Joint Infection

Mild to moderate infections: 1 g IV or intramuscularly every 24 hours. Severe or Life-threatening infections: 2 g IV every 24 hours.

Usual Adult Dose for Osteomyelitis

Mild to moderate infections: 1 g IV or intramuscularly every 24 hours. Severe or Life-threatening infections: 2 g IV every 24 hours.

Usual Adult Dose for Skin and Structure Infection

Mild to moderate infections: 1 g IV or intramuscularly every 24 hours. Severe or Life-threatening infections: 2 g IV every 24 hours.

Usual Adult Dose for Sepsis

Mild to moderate infections: 1 g IV or intramuscularly every 24 hours. Severe or Life-threatening infections: 2 g IV every 24 hours.

Renal Dose Adjustments

CrCl < 5 mL/min:
Mild to moderate infections: Loading dose of 7.5 mg/kg followed by 3 mg/kg IV or intramuscularly every 3 to 5 days.
Severe infections: Loading dose of 7.5 mg/kg followed by 4 mg/kg IV every 3 to 5 days.

CrCl 5 to 9 mL/min:
Mild to moderate infections: Loading dose of 7.5 mg/kg followed by 4 mg/kg IV or intramuscularly every 3 to 5 days.
Severe infections: 15 mg/kg IV every 3 to 5 days.

CrCl 10 to 19 mL/min:
Mild to moderate infections: Loading dose of 7.5 mg/kg followed by 4 mg/kg IV or intramuscularly every 48 hours.
Severe infections: 15 mg/kg IV every 48 hours.

CrCl 20 to 39 mL/min:
Mild to moderate infections: Loading dose of 7.5 mg/kg followed by 4 mg/kg IV or intramuscularly every 24 hours.
Severe infections: 15 mg/kg IV every 24 hours.

CrCl 40 to 9 mL/min:
Mild to moderate infections: 8 mg/kg IV or intramuscularly every 24 hours.
Severe infections: 20 mg/kg IV every 24 hours.

CrCl 60 to 79 mL/min:
Mild to moderate infections: 10 mg/kg IV every 24 hours
Severe infections: 25 mg/kg IV every 24 hours.

Liver Dose Adjustments

No adjustment recommended

Dialysis

It is not necessary to administer additional dosage following dialysis.

Other Comments

When administering 2 g intramuscular doses once daily, 1/2 the dose should be administered in different large muscle masses.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.