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Cefonicid Pregnancy and Breastfeeding Warnings

Cefonicid is also known as: Monocid

Cefonicid Pregnancy Warnings

Cefonicid has been assigned to pregnancy category B. Animal studies failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Cefonicid should only be given during pregnancy when need has been clearly established.

See references

Cefonicid Breastfeeding Warnings

Cefonicid is excreted into human milk in small amounts. Adverse effects in the nursing infant are unlikely.

In one study, cefonicid 1 gram intramuscularly was administered to 10 lactating women. One hour after injection, the average serum and milk levels were 67.4 and 0.16 mcg per mL, respectively. While this represents a miniscule amount of drug to the nursing infant, and no adverse effects on the nursing infants were observed in this study, data are limited. Whether cefonicid milk levels increase after chronic dosing is not known. Cefonicid is poorly absorbed by the adult human gut, but the extent of absorption by the neonatal gut is not known.

See references

References for pregnancy information

  1. "Product Information. Monocid (cefonicid)." SmithKline Beecham, Philadelphia, PA.

References for breastfeeding information

  1. Lou MA, Wu YH, Jacob LS, Pitkin DH "Penetration of cefonicid into human breast milk and various body fluids and tissues." Rev Infect Dis 6 (1984): s816-20
  2. "Product Information. Monocid (cefonicid)." SmithKline Beecham, Philadelphia, PA.
  3. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):

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