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Bismuth Subsalicylate / Metronidazole / Tetracycline Dosage

Medically reviewed by Drugs.com. Last updated on Sep 6, 2024.

Applies to the following strengths: 262.4 mg-250 mg-500 mg

Usual Adult Dose for Helicobacter pylori Infection

524.8 mg bismuth subsalicylate (chewable), metronidazole 250 mg, and tetracycline 500 mg orally four times daily for 14 days with meals and at bedtime. This therapy should be accompanied by a histamine-2 antagonist approved for the treatment of acute duodenal ulcer. The metronidazole tablet and the tetracycline capsule should be swallowed whole with a full glass of water (8 ounces).

Usual Pediatric Dose for Helicobacter pylori Infection

8 years and older: Bismuth subsalicylate 524.8 to 525 mg-metronidazole 250 mg-tetracycline 500 mg orally 4 times a day (after meals and at bedtime)


Comment: An H(2) receptor antagonist approved to treat acute duodenal ulcer should be given with this drug.

Use: Eradication of Helicobacter pylori infection in patients with active or a history of duodenal ulcer

Renal Dose Adjustments

Mild to moderate renal impairment: Data not available
Severe renal impairment: Contraindicated

Liver Dose Adjustments

Mild to moderate hepatic dysfunction (Child-Pugh A and B): Use with caution.
Severe hepatic dysfunction (Child-Pugh C): Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.

Precautions

US BOXED WARNINGS: POTENTIAL FOR CARCINOGENICITY


Safety and efficacy have not been established in patients younger than 8 years.

Consult WARNINGS section for additional precautions

Dialysis

Data not available

Other Comments

Administration advice:


Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.