Akeega Dosage
Generic name: NIRAPARIB TOSYLATE MONOHYDRATE 100mg, ABIRATERONE ACETATE 500mg
Dosage form: tablet, film coated
Drug class: Antineoplastic combinations
Medically reviewed by Drugs.com. Last updated on Aug 19, 2024.
Patient Selection
Select patients for the treatment of mCRPC with AKEEGA based on the presence of a BRCAgene alteration .
Information on FDA-approved tests is available at: http://www.fda.gov/CompanionDiagnostics.
Recommended Dosage
The recommended dosage of AKEEGA is 200 mg niraparib/1,000 mg abiraterone acetate orally once daily in combination with 10 mg prednisone daily until disease progression or unacceptable toxicity.
Patients receiving AKEEGA should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy. Take AKEEGA on an empty stomach. Do not eat food two hours before and one hour after taking AKEEGA. Swallow tablets whole with water. Do not break, crush, or chew tablets.
If a patient misses a dose, instruct patients to take the dose as soon as possible on the same day and resume their next dose at the normal schedule the following day.
Dosage Modification for Adverse Reactions
The recommended dosage modifications for AKEEGA are provided in Table 1.
Treatment with AKEEGA should not be reinitiated until the toxicity has resolved to Grade 1 or baseline. If the toxicity is attributed to one component of AKEEGA, the other component of AKEEGA may be continued as a single agent at the current dose until the adverse reaction resolves and AKEEGA can be resumed (see Table 1).
Adverse Reaction | Severity | Dosage Modification |
---|---|---|
Myelosuppression |
Hemoglobin <8 g/dL |
|
Platelet count <100,000/mcL | First occurrence:
|
|
Neutrophil <1,000/mcL |
|
|
Hematologic adverse reaction requiring transfusion |
|
|
Hepatotoxicity |
ALT and/or AST greater than 5 × ULN or total bilirubin greater than 3 × ULN |
|
Other non-hematological adverse reactions that persist despite medical management | Grade 3 or 4 † |
|
More about Akeega (abiraterone / niraparib)
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Patient resources
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- Akeega prescribing information
- Niraparib Tosylate Monohydrate and Abiraterone Acetate (AHFS Monograph)
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Further information
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