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Acetohydroxamic Acid Dosage

Applies to the following strength(s): 250 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Urinary Tract Infection

Starting dose: 12 mg/kg/day administered at 6 to 8 hour intervals at a time when the stomach is empty.

Then progress to one tablet orally 3 to 4 times a day in a total daily dose of 10 to 15 mg/kg/day.

The maximum daily dose should be no more than 1.5 grams, regardless of body weight.

Usual Pediatric Dose for Urinary Tract Infection

Children with chronic, recalcitrant, urea-splitting urinary infection may benefit from treatment with acetohydroxamic acid. However, detailed studies involving dosage and dose intervals in children have not been established.

Children have tolerated a dose of 10 mg/kg/day, taken in two or three divided doses, satisfactorily for periods up to one year. Therefore, an initial dose of 10 mg/kg/day orally is recommended.

Close monitoring of the patient's clinical condition and hematologic status is recommended. Titration of the dose to higher or lower levels may be required to obtain an optimum therapeutic effect and/or to reduce the risk of side effects.

Renal Dose Adjustments

Because acetohydroxamic acid is eliminated primarily by the kidneys, patients with significantly impaired renal function should be closely monitored, and a reduction of daily dose may be needed to avoid excessive drug accumulation.

Patients whose serum creatinine is greater than 1.8 mg/dL should take no more than 1 gm/day These patients should be dosed at 12 hour intervals. Further reductions in dosage to prevent the accumulation of toxic concentrations in the blood may also be desirable. Insufficient data exists to accurately specify the optimum dose and/or dose interval in patients with moderate degrees of renal insufficiency.

Patients with advanced renal insufficiency (i.e., serum creatinine more than 2.5 mg/dL) should not be treated with acetohydroxamic acid. The risk of accumulation of toxic blood levels of acetohydroxamic acid seems to be greater than the chances for a beneficial effect in such patients.

Liver Dose Adjustments

Data not available

Dialysis

Data specific to use in dialysis patients is not available.

Patients with advanced renal insufficiency (i.e., serum creatinine more than 2.5 mg/dL) should not be treated with acetohydroxamic acid. The risk of accumulation of toxic blood levels of acetohydroxamic acid seems to be greater than the chances for a beneficial effect in such patients.

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