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Acetaminophen / Phenylephrine Dosage

Applies to the following strength(s): 325 mg-5 mg ; 650 mg-10 mg ; 500 mg-15 mg ; 250 mg-5 mg ; 80 mg-1.25 mg ; 500 mg-5 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Nasal Congestion

Acetaminophen 250 mg - phenylephrine 5 mg oral effervescent tablet:
2 tablets fully dissolved in 4 ounces of water every 4 hours.

Acetaminophen 325 mg - phenylephrine 5 mg oral tablet:
2 tablets orally every 4 hours. Do not take more than 12 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 15 mg oral tablet:
2 tablets orally every 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 5 mg oral tablet:
2 tablets orally every 4 to 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 650 mg - phenylephrine 10 mg oral powder:
Dissolve 1 packet in 8 ounces of hot water and drink in 10 to 15 minutes. May repeat every 4 hours. Not to exceed 6 packets daily.

Usual Adult Dose for Sinus Symptoms

Acetaminophen 250 mg - phenylephrine 5 mg oral effervescent tablet:
2 tablets fully dissolved in 4 ounces of water every 4 hours.

Acetaminophen 325 mg - phenylephrine 5 mg oral tablet:
2 tablets orally every 4 hours. Do not take more than 12 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 15 mg oral tablet:
2 tablets orally every 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 5 mg oral tablet:
2 tablets orally every 4 to 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 650 mg - phenylephrine 10 mg oral powder:
Dissolve 1 packet in 8 ounces of hot water and drink in 10 to 15 minutes. May repeat every 4 hours. Not to exceed 6 packets daily.

Usual Adult Dose for Headache

Acetaminophen 250 mg - phenylephrine 5 mg oral effervescent tablet:
2 tablets fully dissolved in 4 ounces of water every 4 hours.

Acetaminophen 325 mg - phenylephrine 5 mg oral tablet:
2 tablets orally every 4 hours. Do not take more than 12 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 15 mg oral tablet:
2 tablets orally every 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 5 mg oral tablet:
2 tablets orally every 4 to 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 650 mg - phenylephrine 10 mg oral powder:
Dissolve 1 packet in 8 ounces of hot water and drink in 10 to 15 minutes. May repeat every 4 hours. Not to exceed 6 packets daily.

Usual Pediatric Dose for Nasal Congestion

Acetaminophen 250 mg - phenylephrine 5 mg oral effervescent tablet:
12 years to 18 years: 2 tablets fully dissolved in 4 ounces of water every 4 hours.

Acetaminophen 325 mg - phenylephrine 5 mg oral tablet:
12 years or older: 2 tablets orally every 4 hours. Do not take more than 12 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 15 mg oral tablet:
12 years or older: 2 tablets orally every 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 5 mg oral tablet:
12 years: years or older: 2 tablets orally every 4 to 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 650 mg - phenylephrine 10 mg oral powder:
12 yrs or older: Dissolve 1 packet in 8 ounces of hot water and drink in 10 to 15 minutes. May repeat every 4 hours. Not to exceed 6 packets daily.

Dose all other formulations based on the acetaminophen component:
2 to 3 years: 160 mg/dose.
4 to 5 years: 240 mg/dose.
6 to 8 years: 320 mg/dose .
9 to 10 years: 400 mg/dose.
11 to 12 years: 480 mg/dose.
13 years or older: 325 to 650 mg/dose.

Maximum: 5 doses/day.

Usual Pediatric Dose for Sinus Symptoms

Acetaminophen 250 mg - phenylephrine 5 mg oral effervescent tablet:
12 years to 18 years: 2 tablets fully dissolved in 4 ounces of water every 4 hours.

Acetaminophen 325 mg - phenylephrine 5 mg oral tablet:
12 years or older: 2 tablets orally every 4 hours. Do not take more than 12 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 15 mg oral tablet:
12 years or older: 2 tablets orally every 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 5 mg oral tablet:
12 years: years or older: 2 tablets orally every 4 to 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 650 mg - phenylephrine 10 mg oral powder:
12 yrs or older: Dissolve 1 packet in 8 ounces of hot water and drink in 10 to 15 minutes. May repeat every 4 hours. Not to exceed 6 packets daily.

Dose all other formulations based on the acetaminophen component:
2 to 3 years: 160 mg/dose.
4 to 5 years: 240 mg/dose.
6 to 8 years: 320 mg/dose .
9 to 10 years: 400 mg/dose.
11 to 12 years: 480 mg/dose.
13 years or older: 325 to 650 mg/dose.

Maximum: 5 doses/day.

Usual Pediatric Dose for Headache

Acetaminophen 250 mg - phenylephrine 5 mg oral effervescent tablet:
12 years to 18 years: 2 tablets fully dissolved in 4 ounces of water every 4 hours.

Acetaminophen 325 mg - phenylephrine 5 mg oral tablet:
12 years or older: 2 tablets orally every 4 hours. Do not take more than 12 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 15 mg oral tablet:
12 years or older: 2 tablets orally every 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 500 mg - phenylephrine 5 mg oral tablet:
12 years: years or older: 2 tablets orally every 4 to 6 hours. Do not take more than 8 tablets in 24 hours.

Acetaminophen 650 mg - phenylephrine 10 mg oral powder:
12 yrs or older: Dissolve 1 packet in 8 ounces of hot water and drink in 10 to 15 minutes. May repeat every 4 hours. Not to exceed 6 packets daily.

Dose all other formulations based on the acetaminophen component:
2 to 3 years: 160 mg/dose.
4 to 5 years: 240 mg/dose.
6 to 8 years: 320 mg/dose .
9 to 10 years: 400 mg/dose.
11 to 12 years: 480 mg/dose.
13 years or older: 325 to 650 mg/dose.

Maximum: 5 doses/day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution in patients with liver disease. Chronic use of acetaminophen is not recommended in patients with liver disease.

Precautions

Acetaminophen-phenylephrine should not be used in patients with heart disease, high blood pressure, diabetes, thyroid disease, or enlargement of the prostate gland.

Patients who consume three or more alcohol containing drinks per day should be informed to consult with their physician for advice on when and how to take acetaminophen. Chronic, heavy alcohol users may be at increased risk of liver damage when taking more than recommended dosages.

Patients should be advised to consult with their doctor before continuing to use acetaminophen if symptoms of illness worsen. Although rare, there is the possibility of acetaminophen intoxication on chronic use of the drug, and the symptoms seen during the first phase of intoxication (nausea, vomiting, anorexia, malaise, and diaphoresis) may trigger the use of more doses.

Do not use phenylephrine in patients with pheochromocytoma.

Dialysis

Data not available

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