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Acetaminophen / phenylephrine Drug Interactions

A total of 452 drugs are known to interact with acetaminophen / phenylephrine.

  • 81 major drug interactions
  • 332 moderate drug interactions
  • 39 minor drug interactions

Show all medications in the database that may interact with acetaminophen / phenylephrine.

Check for interactions with acetaminophen / phenylephrine

Type in a drug name and select a drug from the list.

Common medications checked in combination with acetaminophen / phenylephrine

  • Ambien CR (zolpidem)
  • Bystolic (nebivolol)
  • chlorpheniramine (Chlor-Trimeton, Chlorpheniramine (Allergy), Allergy Relief, Aller-Chlor, Chlorphen, Wal-finate, C.P.M., Chlor-Trimeton Allergy SR, Ricobid H, P-Tann, TanaHist-PD, Ed ChlorPed, Ed-Chlortan, Topco Allergy, Pharbechlor, Teldrin HBP Allergy, Chlor-Mal, Chlo-Amine, PediaTan, ChlorTan, Ed Chlor-Tan, Allergy Time, Ed Chlor Ped Jr., Chlor-Phenit)
  • Claritin (loratadine)
  • Colace (docusate)
  • CoQ10 (ubiquinone)
  • dextromethorphan (Delsym, Dextromethorphan HBr Adult Formula, Delsym 12 Hour Cough Relief, Cough Syrup DM, Buckleys Mixture, Dry Cough, Hold, DexAlone, Benylin DM, Calmylin, Strepsils Cough, Bisolvon Dry, Scot-Tussin Diabetes, Robitussin CoughGels Long-Acting, Robitussin 12-Hour Cough Relief, Vicks Formula 44, Pertussin ES, Babee Cof, Silphen DM, Pertussin DM, Vicks Formula 44 Custom Care Dry Cough Suppressant, Balminil DM, Delsym 12 Hour Cough Relief for Children & Adults, Novahistine DM, Covonia Bronchial Balsam, Robitussin Cough Long-Acting, Triaminic Thin Strips Long Acting Cough, Benadryl for the Family Dry Forte, Theraflu Thin Strips Cough, Neocitran Thin Strips Cough, Contac Cough, Robafen Cough Liquidgels, Jack & Jill Thin Strips Cough, Tussinol for Dry Coughs, Bisolvon Dry Junior, Dristan DM, Dexi-Tuss, Nucosef DM, Strepsils Cough Relief, Delsym Children's 12-Hour Cough Relief, Sucrets Cough, Pedia Relief, Triaminic Long Acting Cough, Creomulsion Children, Creomulsion, Buckley's DM, Buckley's Mixture Cough Suppressant, Tussin Cough Gels (Long Acting), Vicks Nature Fusion Cough, Duract Max Strength Cough, Lloydspharmacy Dry Adult Cough, 12 Hour Cough Relief, Triaminic Thin Strips Cough, ElixSure Cough, Scot-Tussin DM Cough Chasers, Hold DM, Pertussin CS Childrens, Robitussin Children's Cough Long-Acting, St. Joseph Cough Suppressant, PediaCare Children's Long-Acting Cough, Tussin Pediatric, Robafen Pediatric Cough & Cold, Vicks Dayquil Cough)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Diphenhist, Diphen, Unisom SleepGels, Sleep, Diphen Cough, Hydramine, Benadryl Children's Allergy, Sominex, Diphenadryl, Dicopanol, Diphedryl, Diphenydramine Quick Melt, Nytol, Buckley's Bedtime, 40 Winks, DPH, Q-Dryl, Sleep-Eze-3, Valu-Dryl, Diphenyl, Beldin, Vicks QlearQuil Nighttime Allergy Relief, Sleep-ettes, Allermax, Diphendryl, Q-Dryl A/F, Histaprin, Tranquil Nighttime Sleep Aid, Dormin, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen AF, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Aller-G-Time, Sleep Tab II, Sleep Tabs, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Belix, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Quenalin, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Pharbedryl, Z-Sleep, Unisom SleepMelts, PediaCare Children's Allergy, Truxadryl, Simply Sleep, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • Effexor XR (venlafaxine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Keflex (cephalexin)
  • Mirena (levonorgestrel)
  • OxyContin (oxycodone)
  • Paracetamol (acetaminophen)
  • phenylephrine (Neo-Synephrine, Sudafed PE Congestion, Phenyl-T, Nasal Decongestant PE, Congest Aid II, Nasop, Vazculep, Suphedrine PE, Help I Have A Stuffy Nose, Despec-SF, Sudogest PE, Nasop12, Triaminic Thin Strips Cold with Stuffy Nose, Dimetapp Toddler's Drops Decongestant, AH-Chew D, Gilchew IR, Little Colds Decongestant, Lusonal, Contac-D, Ricobid-D, PediaCare Children's Decongestant, Sudafed PE Children's Nasal Decongestant)
  • Pristiq (desvenlafaxine)
  • Provigil (modafinil)
  • Rozerem (ramelteon)
  • Tylenol Extra Strength (acetaminophen)
  • Vitamin C with Rose Hips (ascorbic acid)
  • Vitamin D2 (ergocalciferol)

acetaminophen / phenylephrine alcohol/food Interactions

There is 1 alcohol/food interaction with acetaminophen / phenylephrine

acetaminophen / phenylephrine disease Interactions

There are 7 disease interactions with acetaminophen / phenylephrine which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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